Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-13
1999-09-07
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 6, 514 34, A61K 3135, A61K 3816, A61K 3170
Patent
active
059488158
ABSTRACT:
The invention provides methods and compositions for reducing microbial cytotoxicity to a cell, by contacting a cell subject to extracellular microbial cytotoxicity with an effective amount of at least one of genistein or a genistein derivative. In preferred embodiments, the microbe is a gram-negative bacterium, a non-Enterobacteriaceae or a Pseudomonas aeruginosa or cepacia and the host cell is a mammalian epithelial cell, especially a lung epithelial cell or a corneal epithelial cell. The genistein or genistein derivative may be administered prophylactically prior to infection, subsequent thereto and/or in conjunction with conventional antibiotic therapies.
REFERENCES:
Sandros et al. Cellular Events concurrent with Porphyromonas Gingivalis Invasion of Oral Epithelium In Vitro. Europ. J. Oral Sci. 1996 vol. 104, pp. 363-371, see abst.
Ralph et al. Resistance of Melanoma Cell Lines to Interferons Correlates with Reduction of IFN-Induced Tyrosine Phosphorylation: Induction of the Anti-Viral State by IFN is Prevented by Tyrosine Kinase Inhibitors. J. Immunol. 1995, vol. 154, No. 5, pp. 2248-2256, see abst.
Valentin-Weigand et al. Characterization of Group B Streptococcal Invasion in HEP-2 Epithelial Cells. FEMS Microbiol. Letters. Feb. 1997. Vo. 147, pp. 69-75, esp. p. 70, 2.sup.nd col.
Bandyukova et al., Chemical Abstract 108:71937 (1987) copy of abstract.
Windholz et al. The Merck Index (1983) abstracts Nos. 937, 4251, and 9318.
Evans David J.
Fleiszig Suzanne M. J.
Osman Richard Aron
The Regents of the University of California
Weddington Kevin E.
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