Methods for inhibiting angiogenesis, proliferation of endothelia

Details Methods for inhibiting angiogenesis, proliferation of endothelia Methods for inhibiting angiogenesis, proliferation of endothelia

1994-12-13

1998-12-01

Sayala, Chhaya D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

514154, 514765, 514768, 424469, 424470, A61K 3165, A61K 926

Patent

active

058439250

ABSTRACT:
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.

REFERENCES:
patent: 3226436 (1965-12-01), Petisi et al.
patent: 3518306 (1970-06-01), Martell et al.
patent: 5248797 (1993-09-01), Sum
patent: 5268384 (1993-12-01), Galardy
patent: 5328902 (1994-07-01), Sum et al.
patent: 5563130 (1996-10-01), Backer et al.
patent: 5567693 (1996-10-01), Backer et al.
patent: 5574026 (1996-11-01), Backer et al.
Guerin. C. et al, Selective Endothelial Growth Inhibition by Tetracyclines that Inhibit Collagenase, Biochemical and Biophysical Research Communications, vol. 188, No. 2, 740-745, 1992.
Bogert, C. van den et al, Arrest of in Vivo Proliferation of Zajdela Tumor Cells by Inhibition of mitochondrial protein Synthesis, Cancer Research 41, 194-1947, May 1981.
Teicher, B. A. et al, Antiangiogenic Agents Potentiate Cytotoxic Cancer Therapies against Primary and Metastatic Disease, Cancer Research 52, 6702-6704, Dec. 1992.
Monks, A. et al, Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines, Journal of the National Cancer Institute, vol. 83, No. 11, 757-766, Jun. 1991.
Sotomayor, E. A. et al, Minocycline in combination with chemotherapy or radiation therapy in vitro and in vivo, Cancer Chemotherapy and Pharmacology, 30:377-384, 1992.
Leezenberg, J.A. et al, Possible Cytostatic Action of Tetracyclines in the Treatment of Tumors of the Nasopharynx and Larynx, European Journal of Clinical Pharmacology, 16, 237-241, 1971.
Tamargo, R. et al, Angiogenesis Inhibition by Minocycline, Cancer Research 51, 672-675, Jan. 1991.
Kroon A.M. et al, The Antitumour Action of Doxycycline, Drugs Exptl. Clin. Res., X(11), 759-766, 1984.
Bogert C. van den, Arrest of the Proliferation of Renal and Prostate Carcinomas of Human Origin by Inhibition of Mitochondrial Protein Synthesis, Cancer Research, 46, 3283-3289, Jul. 1986.
Pruzanski, W. et al, Inhibition of Enzymatic Activity of Phospholiphases A.sub.2 by Minocycline and Doxycycline, Biochemical Pharmacology, vol. 44, No. 6, 1165-1170, 1992.
Golub, L.M. et al, Host Modulation with Tetracyclines and their Chemically Modified Analogues, Periodontology and Restorative Dentistry, 80-90, 1992.
Golub, L. M. et al Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs, Critical Reviews in Oral Biology and Medicine, 2(2):297-322 (1991).
Zucker, S. et al, Diversity of Melanoma Plasma Membrane Proteinases: Inhibition of Collagenoloytic and Cytolytic Activities by Minocycline, JNCI. vol. 75, No. 3, Sep. 1985.
Greenwald R. A., et al, Tetracyclines Inhibit Human Synovial Collagenase in Vivo and In Vitro, The Journal of Rheumatology 1987: 14:1.
Hlavka, J. et al, The 6-Deoxytetracyclines.III.Electrophilic and Nucleophilic Substitution J. AM. Chem. Soc., 84, 1420, 1962.

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