Methods for inhibiting angiogenesis and tumor growth

Details Methods for inhibiting angiogenesis and tumor growth Methods for inhibiting angiogenesis and tumor growth

2008-05-06

2008-05-06

Pryor, Alton (Department: 1616)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

C514S483000, C514S506000, C514S532000, C514S613000, C514S617000

Reexamination Certificate

active

11439918

ABSTRACT:
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3are inhibited by an inhibitor compound of formula:wherein G1and G2are each independently —NH—C(O)—O—(CH2)v—(C6H4)—X3; Y1and Y2are each independently —OH or C1-C4alkoxy; X1and X2are each independently halo or C1-C4alkoxy; X3is fluoro, nitro, C1-C4alkyl, C1-C4alkoxy, or C1-C4perfluoroalkyl; Z is —C≡C—, —C6H4—, cis-CH═CH—, trans-CH═CH—, cis-CH2—CH═CH—CH2—, trans-CH2—CH═CH—CH2—, 1,4-naphthyl, cis-1,3-cyclohexyl, trans-1,3-cyclohexyl, cis-1,4-cyclohexyl, or trans-1,4-cyclohexyl; A is H or a covalent bond; m and n are each 1; t is an integer having a value of 0 or 1; p and r are each 2, and v is 1; with the proviso that when A is H, t is 0, and when A is a covalent bond, t is 1.

REFERENCES:
patent: 2003/0078296 (2003-04-01), Boger et al.

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