Methods for inhibiting and breaking AGE complex formation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S596000, C514S601000, C514S632000

Reexamination Certificate

active

08048896

ABSTRACT:
Various methods of administering medication(s) that inhibit the nonenzymatic formation of glycation and dehydration condensation complexes known as advanced glycation end-products (AGEs) or modulate the advanced glycation end-product receptor (RAGE) are provided.

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patent: 2004/0137068 (2004-07-01), Bhushan
Miyata et al., Mechanism of Inhibitory Effect of OPB-9195 [(±)-2-Isopropylidenehydranzono-4-oxo-thiazolidin-5-ylacetanilide] on Advanced Glycation End Products and Advanced Lipoxidation End Product Formation, Journal of American Society of Nephrology, vol. 11, No. 9, pp. 1719-1725 (2000) in view of Bhushan (US 2004/0137068 A1).

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