Methods for inducing site-specific immunosuppression and composi

Details Methods for inducing site-specific immunosuppression and composi Methods for inducing site-specific immunosuppression and composi

1994-06-24

1996-07-30

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424435, 424436, 424449, 514 9, 514 11, 514 43, 514252, 514258, 514291, 514323, 514368, 514614, A61K 3813

Patent

active

055409318

ABSTRACT:
The present invention provides methods and formulations for site-specific immune suppression of immune/inflammatory responses with localized or topical application of immunosuppressants including cyclosporines, rapamycins (RPM), or combinations of immunosuppressants and anti-inflammatory compounds. Methods for the use of said formulations to effect site-specific immune suppression of local inflammatory/immune responses in mammalian tissue and for treatment of autoimmune, T-cell mediated immune disease, inflammatory conditions, inhibition of contact hypersensitivity, and for producing prolonged skin allograft survival, and wound healing are presented. In addition, methods for use of said formulations--in tandem with systemic applications of immunosuppressant such as cyclosporine or without same--are presented. The present invention also relates to alternative formulations and delivery systems for the efficacious treatment of the aforementioned conditions.

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