Methods for inducing HIV-neutralizing antibodies

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex

Reexamination Certificate

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C424S188100, C424S194100, C424S196110, C424S208100, C530S330000, C530S324000, C530S350000

Reexamination Certificate

active

07056519

ABSTRACT:
The present invention relates to a method for inducing antibodies neutralizing HIV primary isolates in a mammal, comprising administration of a pharmaceutical composition comprising a polypeptide represented by the formula N-L-C, in which:N represents the amino acid sequence 25–81 of gp41,C represents the amino acid sequence 112–157 of gp41, andL represents a flexible linking sequence comprising from 2 to 30 amino acids.

REFERENCES:
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patent: WO 00 40616 (2000-07-01), None
patent: WO 01 44286 (2001-06-01), None
patent: WO 01 70262 (2001-09-01), None
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