Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-06-01
1989-03-28
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530395, 530840, C07C 800, A61K 3702
Patent
active
048164372
ABSTRACT:
The present invention provides unique methodologies for inducing new bone apposition in-vivo generally or at a localized site and for therapeutically treating a subject afflicted with a pathological disorder of bone which is characterized by a deficiency of calcium ions in the bone matrix. The methodology for treating generalized defective skeletile mineralization comprises administering sufficient quantities of .alpha..sub.2 HS-glycoprotein to the subject such that the concentration of this naturally occurring plasma protein is not substantially less than about 600 micrograms per milliliter of serum in-vivo. Alternatively, the method for treatment of localized defective skeletile mineralization comprises administration of a therapeutic admixture containing about 300 mircograms of .alpha..sub.2 HS-glycoprotein per gram of filler material to the site of skeletal defect.
REFERENCES:
Lewis et al., "Effect of Human .alpha..sub.2 HS Glycoprotein on Mouse Macrophage Function", Immunology, 1980, 39:317.
Gejyo et al., "Purification and Characterization of the Two Forms of Human Plasma .alpha..sub.2 HS-Glycoprotein", Biochim. Biophys. Acta, 671, (1981), 78-84.
Colclasure Craig
Lloyd Weldon S.
Nimberg Richard B.
Kight John
Nutter Nathan M.
Prashker David
Trustees of Boston University
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