Methods for inducing differentiation of undifferentiated...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S007100, C506S007000, C530S350000, C530S325000, C530S324000

Reexamination Certificate

active

07638288

ABSTRACT:
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts, including bone formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject.

REFERENCES:
patent: 6340595 (2002-01-01), Vogels et al.
patent: 7192583 (2007-03-01), Brunkow et al.
patent: 2003/0180258 (2003-09-01), van Es et al.
patent: 2003/0186360 (2003-10-01), Feder et al.
patent: 2003/0198627 (2003-10-01), Arts et al.
patent: 2004/0071660 (2004-04-01), Havenga et al.
patent: 2004/0101818 (2004-05-01), Ji et al.
patent: 2006/0252045 (2006-11-01), Chatterjee-Kishore et al.
patent: WO0177172 (2001-10-01), None
patent: WO03012070 (2003-02-01), None
patent: WO03018799 (2003-03-01), None
patent: WO03099867 (2003-12-01), None
patent: WO2004094636 (2004-11-01), None
patent: WO2005063976 (2005-07-01), None
patent: WO2005063983 (2005-07-01), None
Arts, Gert-Jan., et al; “Adenoviral Vectors Expressing siRNAs for Discovery and Validation of Gene Function”; Genome Research, vol. 13, No. 10, pp. 2325-2332 (2003) Cold Spring Harbor Laboratory Press USA.
Brummelkamp, Thijn R., et al.; “Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB”; Nature (London), vol. 424, No. 6950, pp. 797-801 (2003) Nature Publishing Group, London UK.
Franceschi, RT and Xiao, G.; “Regulation of the Osteoblast-Specific Transcription Factor, Runx2: Responsiveness to Multiple Signal Transduction Pathways”, Journal of Cellular Biochemistry 88:446-454 (2003) Wiley-Liss, Inc. USA.
Golde, B.; “New Clues into the Etiology of Osteoporosis: The Effects of Prostaglandins (E2 and F2a) on Bone”; Medical Hypotheses, vol. 38, No. 2, pp. 125-131 (1992) Elsevier Science ltd. Publishers USA.
Harris, S.E., et al; “Effects of Transforming Growth Factor B on Bone Nodule Formation and Expression of Bone Morphogenetic Protein 2, Osteocalcin, Osteopontin, Alkaline Phosphatase, and Type I Collagen mRNA in Long-Term Cultures of Fetal Rate Calvarial Osteoblasts”; Journal of Bone and Mineral Research, vol. 9, No. 6, pp. 855-863 (1994) Mary Ann Liebert, Inc. Publishers USA.
Marzia, M., et al; “Decreased c-SCR Expression Enhances Osteoblast Differentiation and Bone Formation”; The Journal of Cell Biology, vol. 151, No. 2 pp. 311-320 (2000) The Rockefeller University Press USA.
Michiels, Frits, et al., “Arrayed adenoviral expression libraries for functional screening”; Nature Biotechnology, vol. 20, No. 11, pp. 154-1157 (2002) Nature Publishing Group USA.
Mundy, Gregory R., M.D.; “Cytokines and Growth Factors in the Regulation of Bone Remodeling”; Journal of Bone and Mineral Research, vol. 8, Suppl. 2, pp. S505-S510 (1993) Mary Ann Liebert, Inc. Publishers USA.
Mundy, Gregory R., M.D.; “Role of LCytokines in Bone Resorption”; Journal of Cellular Biochemistry, vol. 53 pp. 296-300 (1993) Wiley-Liss, Inc. USA.
Mundy, Gregory R., M.D., “Regulation of Bone Formation by Bone Morphogenetic Proteins and Other Growth Factors”; Clinical Orthopaedic and Related Research, No. 323, pp. 24-28 (1996) Lippinoctt-Raven Publishers USA.
Nakashima, K. and de Crombrugghe, B., “Transcriptional Mechanisms in Osteoblast Differentiation and Bone Formation”; Trends in Genetics, vol. 19, No. 8 pp. 458-466 (2003) Elsevier Ltd USA.
Service, Robert F., “Tissue Engineers Build New Bone”; Science Magazine, vol. 289, No. 5484, pp. 1498-1500 (2000) USA.
Sloper-Mould, Katherine E., et al., “Characterization and Chromosomal Localization of USP3, a Novel Human Ubiquitin-Specific Protease”; Journal of Biological Chemistry, vol. 274, No. 38, pp. 26878-26884 (1999) The American Society for Biochemistry & Molecular Biology, Inc. USA.
Stein, et al., “Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation”; Cell Growth and Gene Expression, The FASEB Journal, vol. 4, pp. 3111-3123 (1990) USA.
Thirunavukkarasu, et al., The Osteoblast-specific Transcription Factor Cbfa1 Contributes to the Expression of Osteoprotegerin, a Potent Inhibitor of Osteoclast Differentiation and Function, The Journal of Biological Chemistry, vol. 275, No. 3, pp. 25163-25172 (2000) JBC Papers in Press USA.
Yamada, et al.; Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells; Blood, vol. 101, No. 6, pp. 2227-2234 (2003) The American Society of Hematology USA.
Zang, et al., “A RUNX2/PEBP/2alphaA/CBFAI mutuation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia”; PNAS, vol. 97, No. 19, pp. 10549-10554 (2000) Proc. Natl. Acad. Sci USA.

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