Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-05-01
2007-05-01
Gambel, Phillip (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S144100, C424S138100, C424S174100, C530S388800, C530S388730, C530S389700, C530S389600
Reexamination Certificate
active
10774708
ABSTRACT:
The present invention is directed to compositions and methods to modulate inflammatory and immune responses in a subject, which includes immune activation and inhibiting inflammatory responses, by modulating the regeneration and tolerance factor (RTF).
REFERENCES:
patent: 5196526 (1993-03-01), Beaman
patent: 6133434 (2000-10-01), Buell et al.
patent: 6524825 (2003-02-01), Mizzen et al.
patent: WO 95/33048 (1995-12-01), None
Abbas et al., Basic Immunology 2ndEd., Saunders Press, pp. 1-4 and 25-27 (2004).
Boomer et al., Human Immunology 61:959-971 (2000).
Aslakson et al., Am J Hematol. May 1999;61(1):46-52.
Boomer, J.S., et al., Regeneration and tolerance factor is expressed during T-lymphocyte activation and plays a role in apoptosis. Hum Immunol, 2001. 62(6): p. 577-88.
Boomer, J.S., et al.,Regeneration and tolerance factor's potential role in T-cell activation and apoptosis. Hum Immunol, 2000. 61(10): p. 959-71.
DuChateau, B.K., et al.Increased expression of regeneration and tolerance factor in individuals with human immunodeficiency virus infection. Clin. Diagn. Lab Immunol., Mar. 1999 6(2): 193-8. Abstract.
Filippini, A., et al.,Ecto-ATPase activity in cytolytic T-lymphocytes. Protection from the cytolytic effects of extracellular ATP. J Biol Chem, 1990. 265(1): p. 334-40.
Gargett, C.E., J.E. Cornish, and J.S. Wiley,ATP, a partial agonist for the P2Z receptor of human lymphocytes. Br J Pharmacol, 1997. 122(5): p. 911-7.
Granstein, R.,The skinny on CD39 in immunity and inflammation. Nature Medicine, Apr. 2002. vol. 8, No. 4: p. 336-338.
Labasi JM, P.N., Donovan C, McCurdy S, Lira P, Payette MM, Brissette W, Wicks JR, Audoly L, Gabel CA.,Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol, 2002. 168(12)(Jun. 15): p. 6436-45.
Lee, C. et al.,Cloning of a cDNA for a T Cell Produced Molecule with a Putative Immune Regulatory Role. Molecular Immunology, 1990. vol. 27, No. 11, p. 1137-1144.
Lee, G. W., Boomer, J.S., Gilman-Sachs, A., Chedid A., Gudelj, L., Rukavina, D. and Beaman, K. D.Regeneration and tolerance factor of the human placenta induces IL-10 induction. Eur J Immunol, 2001. 31: p. 687-691.
Mandal, M. and K.D. Beaman,Purification and Characterization of a Pregnancy-Associated Protein: TJ6s. AJRI, 1995. 33:60-67.
Mizumoto, N., et al.,CD39 is the dominant Langerhans cell-associated ecto-NTP Dase: modulatory roles in inflammation and immune responsiveness. Nat Med, 2002. 8(4): p. 358-65.
Pizzo, P., et al.,Extracellular ATP causes lysis of mouse thymocytes and activiates a plasma membrane ion channel. Biochem. J., 1991. 274: p. 139-144.
Rodriguez, A., et al.,Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells. The Journal of Cell Biology, 1997. vol. 137: p. 93-103.
Toyomura, T., et al.,Three subunit a isoforms of mouse vacuolar H(+)-ATPase. Preferential expression of the a3 isoform during osteoclast differentiation. J Biol Chem, 2000. 275(12): p. 8760-5.
Wiley, J.S., et al.Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel. The American Physiologicial Society, 1998. C1224-C1232.
Wiley et al.,The P2z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP. Br. J. Pharmacol. 1994 112, 946-950.
Everest Intellectual Property Law Group
Gambel Phillip
Rosalind Franklin University of Medicine and Science
Skelding Zachary
Young Tin-Chuen
LandOfFree
Methods for inducing apoptosis in ovarian carcinoma cells... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for inducing apoptosis in ovarian carcinoma cells..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for inducing apoptosis in ovarian carcinoma cells... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3744128