Methods for inducing a mucosal immune response

Details Methods for inducing a mucosal immune response Methods for inducing a mucosal immune response

1998-02-04

2000-10-03

Saunders, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241991, 4242341, 4242781, 4242821, 424812, 514 44, A61K 3900

Patent

active

061269387

ABSTRACT:
The invention relates to a pharmaceutical composition intended for inducing in a host mammal a protective immune response against an antigen, at a mucosal effector site, which comprises at least two identical or different products each containing an inducing agent for the immune response, selected from the antigen and, provided the antigen is protein in nature, an expression cassette capable of expressing the antigen, for a concomitant or consecutive administration; one of the products being formulated so as to be administered via the nasobuccal route so that the inducing agent is targeted to the inducer site(s) for an immune response in the naso-oropharynx or the salivary glands, the other product being formulated so as to be administered via a suitable mucosal route other than the nasal route, so that the inducing agent is targeted to the inducer site(s) for an immune response at the effector site at which the immune response is sought. Optionally, such a composition can also comprise a third product, identical to or different from the first two, formulated for systemic administration.

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McGhee et al, vaccine, 10, 75-88, 1992.
Gallichman et al, Jour. infect. Diseases, 168, 622-629, 1993.

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