Methods for increasing the circulation half-life of protein-base

Details Methods for increasing the circulation half-life of protein-base Methods for increasing the circulation half-life of protein-base

1996-01-17

1998-07-14

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, A61K 9127

Patent

active

057800545

ABSTRACT:
Methods of increasing the circulation half-life of protein-based therapeutics in a host, the methods comprising: (a) administering to the host an amount of a first liposome formulation comprising liposomes and an antineoplastic agent; and (b) administering to the host a second formulation comprising the protein-based therapeutic, wherein the amount of the first liposome formulation is sufficient to suppress an immune response to the protein-based therapeutic of the second formulation, thereby increasing the circulation half-life of the protein-based therapeutic.

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