Methods for increasing arousal and alertness and for the amelior

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514221, 514250, 514263, 514264, 514293, 514450, A61K 3152, A61K 3155

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active

052486788

ABSTRACT:
A method of treating comatose patients or near-comatose patients to increase their arousal and alertness as measured by the Glascow Coma Score by administering effective amounts of an adenosine receptor antagonist and a GABA agonist, either concomitantly in any order including simultaneously, or by administering an adenosine receptor antagonist as the sole active agent. The methods of administration are intravenous bolus or drip injection, subcutaneous injection or orally.

REFERENCES:
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4201861 (1980-05-01), Mrozik et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4333925 (1982-06-01), Buhs et al.
patent: 4495187 (1985-01-01), Sarges
patent: 4547501 (1985-10-01), Sarges
patent: 4963667 (1990-10-01), Chiu et al.
patent: 5189026 (1993-02-01), Costa
Caronna, Rehabilitation of the Head Injured Adult, Rosenthal et al, eds., F. A. Davis Co., Philadelphia, Pa. Chapter 5, 59-73 (1983).
Adams, et al., Principles of Neurology, Fourth Edition, 275-290, (1989) McGraw-Hill, N.Y., Publisher.
Yen-Koo, et al., Pharmacol. 25, 111-115 (1982).
Bridges, et al., Ann. Rep. Med. Chem. 23, 39-48 (1988).
Gualtieri, Brain Injury, 2, (2) 101-129, (1988).
van Woerkom, et al., Eur. Neurol. 21, 227-234 (1982).
Haig, et al., Arch. Phys. Med. Rehabil. 71, 1081-1083 (1990).
Williams, J. Med. Chem. 26(5), 619-628 (1983).
Gautier, et al., J. Appl. Physiol. 49(5), 769-777 (1980).
Horn, Arch. Phys. Med. Rehabil. 73, S-317-S-319 (1991).
McLellan, Physical Medicine and Rehabilitation, Sandel et al, Editors, 4(3), 389-407 (Oct. 1990).

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