Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1997-02-11
1999-01-12
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 43, 424434, 424435, 424436, 514476, 514491, 514212, 514332, 514336, 514514, 514351, 514422, 514428, A61K 9127, A61K 3127, A61K 3155, A61K 3144
Patent
active
058584021
ABSTRACT:
In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in vivo to a suitable scavenger. The resulting complex renders the cyanide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods.
REFERENCES:
patent: 4160452 (1979-07-01), Theeuwes
patent: 4256108 (1981-03-01), Theeuwes
patent: 4265874 (1981-05-01), Bosen et al.
patent: 5357703 (1994-10-01), Lai
Hanesel et al. Pharm. Ztg 118 (26) pp. 987-990, (English Abst & Gen Article, 1973.
Baskin et al., "The Antidotal Action of Sodium Nitrite and Sodium Thiosulfate Against Cyanide Poisining" J. Clin. Pharmacol., 32:368-375 (1992).
Bates et al., "Nitric Oxide Generation from Nitroprusside by Vascular Tissue" Biochem. Pharmacol., 42:S157-S165 (1991).
Dreisbach and Robertson, "Handbook of Poisoning: Prevention, Diagnosis and Treatment," 12th edn., Appleton & Lange, Los Altos, CA, p. 251 (1987).
Houeto et al., "Relation of blood cyanide to plasma cyanocobalamin concentration after a fixed dose of hydroxocobalamin in cyanide Poisoning" Lancet, 346:605-608 (1995).
Kanthasamy et al., "Dopaminergic Neurotoxicity of Cyanide: Neurochemical, Histological, and Behavioral Characterization" Toxicol. App. Pharmacol., 126:156-163 (1994).
Kowaluk et al., "Metabolic Activation of Sodium Nitroprusside to Nitric Oxide in Vascular Smooth Muscle" J. Pharm. Exp. Therap., 262(3):916-922 (1992).
Lai and Komarov, "Spin trapping of nitric oxide produced in vivo in septic-shock mice" FEBS Lett., 345:120-124 (1994).
Myers et al., "Comparison of Tests for Detecting Leaks in the Low-Pressure System of Anesthesia Gas Machines" Anasth. Analg., 84:179-184 (1997).
Ruokonen et al., "Regional blood flow and oxygen transport in patients with the low cardiac output syndrome after cardiac surgery" Crit. Care Med., 21(9):1304-1311 (1992).
Sadoff et al., "Rapid Death Associated With Laetrile Ingestion" J. Am. Med. Assoc., 239(15):1532 (1978).
Scharf et al., "Comparison of Methemoglobin Formers in Protection Against the Toxic Effects of Cyanide" Gen. Pharmacol., 23(1):19-25 (1992).
Shinobu et al., "Sodium N-Methyl-D-glucamine Dithiocarbamate and Cadium Intoxication" Acta Pharmacol et Toxicol., 54:189-194 (1984).
Solomonson, L. P., "Cyanide as a Metabolic Inhibitor" Cyanide in Biology, (B. Vennesland et al., Eds.) Academic Press, New York. pp. 11-28 (1981).
Vessy and Cole, "Blood Cyanide and Thiocyanate Concentrations Produced by Long-Term Therapy With Sodium Nitroprusside" Br. J. Anaeth., 57:148-155 (1985).
Yamamoto, "Protection against cyanide-induced convulsions with .alpha.-ketoglutarate" Toxicol., 61:221-228 (1990).
Kishore Gollamudi S.
Medinox Inc.
Reiter Stephen E.
LandOfFree
Methods for in vivo reduction of cyanide levels and compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for in vivo reduction of cyanide levels and compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for in vivo reduction of cyanide levels and compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1512320