Methods for in vitro fertilization

Details Methods for in vitro fertilization Methods for in vitro fertilization

2005-01-04

2005-01-04

Tate, Christopher R. (Department: 1654)

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

C435S366000, C435S374000, C435S404000

Reexamination Certificate

active

06838235

ABSTRACT:
Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are carried out. In one implementation, the culture media specifically formulated to provide a physical environment similar to that found within the female reproductive tract and conducive to growth and development of human reproductive cells during the various stages of the IVF process. In this regard, specifically formulated culture media can be applied to support the reproductive cells in one or more of the following procedures: oocyte retrieval and handling; oocyte maturation; ordinary fertilization; oocyte, zygote and embryo examination and biopsy; embryonic development to the eight-cell stage; embryonic development to the blastocyst stage; embryo transfer; and cryopreservation.

REFERENCES:
patent: 4007087 (1977-02-01), Ericsson
patent: 4327177 (1982-04-01), Shrimpton
patent: 4804537 (1989-02-01), Bergman
patent: 5096822 (1992-03-01), Rosendrans, Jr. et al.
patent: 5432160 (1995-07-01), Hara et al.
patent: 5496720 (1996-03-01), Susko-Parrish et al.
patent: 6010448 (2000-01-01), Thompson
patent: 6130086 (2000-10-01), Nakazawa et al.
patent: 2199663 (1998-09-01), None
patent: 86109103.1 (1986-07-01), None
patent: 92305952.1 (1992-06-01), None
patent: 0872 80 (1998-10-01), None
patent: WO 8607377 (1986-12-01), None
patent: WO 9967364 (1999-12-01), None
Quinn et al., “Improved Pregnancy Rate in Human In Vitro Fertilization with the Use of a Medium Based on the Composition of Human Tubal Fluid,”Fertility and Sterility, 44,pp. 493-498, 1985; published by Elsevier Science, New York.
E. Roth et al., “Influence of Two Glutamine-Containing Dipeptides on Growth of Mammalian Cells,”In Vitro Cellular&Devel Biol. 24(7), pp. 696-698; 1988; published by Tissue Culture Assoc, Inc.
Jones et al., “Evolution of a Culture Protocol for Successful Blastocyst Development and Pregnancy,”Human Repro 88,pp. 361-368, 1990; published by Journals of Reproduction & Fertility Ltd., Cambridge.
Gardner et al., “Concentrations of Nutrients in Mouse Oviduct Fluid and Their Effects on Embryo Development and Metabolism In Vitro,”J. Repro&Fertility 88,pp. 361-368, 1990; published by Journals of Reproduction & Fertility Ltd., Cambridge.
D. G. Hammitt et al., “Improved Methods for Preparation of Culture Media for in-vitro Fertilization and Gamete Intra-Fallopian Transfer”Human Repro 5(4), pp. 457-463, 1990.
H. J. Leese, “The Environment of the Preimplantation Embryo” fromEstablishing a Successful Human Pregnancy,inSerono Symposia Publications from Raven Press 66,pp. 143-154, 1990; R. G. Edwards, editor.
J. Yovich and G. Grudzinskas, fromThe Management of Infertility. A Manual of Gamete Handling Procedures,Heinemann Professional Publishing, Ltd., pp. 106-195, 1990.
Lane et al., “Effect of Incubation Volume and Embryo Density on the Development and Viability of Mouse Embryos In Vitro,”Human Repro 7,pp. 558-562, 1992; published by Oxford Univ. Press, Oxford.
Gardner et al., Mouse Embryo Cleavage, Metabolism and Viability: Role of Medium Composition,Human Repro 8,pp. 288-295, 1993; published by Oxford Univ. Press, Oxford.
Gardner et al., “Embryo Culture Systems,”Handbook of in vitro Fertilization,A.O. Trounson & D.K. Gardner, eds., pp. 85-114, 1993; published by CRC Press, Boca Raton, FL.
Gardner et al., “Amino Acids and Ammonium Regulate Mouse Embryo Development in Culture,”Biol. Repro 48,pp. 377-385, 1993; published by the Society for the Study of Reproduction, Madison, WI.
Lane et al., “Increase in Postimplantation Development of Cultured Mouse Embryos by Amino Acids and Induction of Fetal Retardation and Exencephaly by Ammonium Ions,”J Repro&Fertility 102,pp. 305-312, 1994; published by Journals of Reprodcution & Fertility Ltd., Cambridge.
Gardner et al., “Enhanced Rates of Cleavage and Development for Sheep Zygotes Cultured to the Blastocyst Stage in Vitro in the Absence of Serum and Somatic Cells: Amino Acids, Vitamins, and Culturing Embryos in Groups Stimulate Development,”Biol Repro 50,pp. 390-400, 1994; published by the Society for the Study of Reproduction, Madison, WI.
Gardner, David K., “Mammalian Embryo Culture in the Absence of Serum or Somatic Cell Support,”Cell Biol. Int'l 18,pp. 1163-1179, 1994; published by Academic Press, London.
Barnes et al., “Blastocyst Development and Birth After In-Vitro Maturation of Human Primary Oocytes, Intracytoplasmic Sperm Injection and Assisted Hatching,”Human Repro,pp. 3243-3247, 1995; published by Oxford Univ. Press, Oxford.
Gardner et al., “Alleviation of the ‘2-Cell Block’ and Development to the Blastocyst of CFI Mouse Embryos: Role of Amino Acids, EDTA and Physical Parameters,”Human Repro 11,pp. 2703-2712, 1996; published by Oxford Univ. Press, Oxford.
J.K. O'Brien et al., “Development Capacity, Energy Metabolism and Ultrastructure of Mature Oocytes from Prepubertal and Adult Sheep”Repro Fertil Devel 8,pp. 1029-1037, 1996.
R.D. Schramm et al., “Development of in-vitro-fertilized Primate Embryos into Blastocysts in a Chemically Defined, Protein-Free Culture Medium,”Human Repro 11,(8), pp. 1690-1697, 1996; published by European Society for Human Reproduction and Embryology.
Gardner et al., “Complex Physiologically Based Serum-Free Culture Media Increase Mammalian Embryo Development”, pp. 187-191, 1997.
Gardner et al., “Culture and Selection of Viable Blastocysts; A Feasible Proposition for Human IVF?,”Human Repro Update 3,pp. 367-382, 1997; published by Oxford Univ. Press, Oxford.
Lane et al., “Differential Regulation of Mouse Embryo Development and Viability by Amino Acids,”J Repro&Fertility 109,pp. 153-164, 1997; published by Journals of Reproduction & Fertility Ltd., Cambridge.
Lane et al., “Nonessential Amino Acids and Glutamine Decrease the Time of the First Three Cleavage Divisions and Increase Compaction of Mouse Zygotes In Vitro,”J Assisted Repro and Genetics 14,pp. 398-403, 1997; published by Kluwer, New York.
Abeyderra et al., Fertilization ant Subsequent Development in vitro of Pig Oocytes Inseminated in a Modified Tris-Buffered Medium with Frozen-hawed Ejaculated Spermatozoa,Biol Repro 57,pp. 729-734, 1997.
Keskintepe et al., Caprine Blastocyst Formation Intracytoplasmic Sperm Injection and Defined Culture,Zygote 5(3), pp. 261-265, 1997.
Gardner et al., “Culture and Transfer of Human Blastocysts Increases Implantation Rates and Reduces the Need for Multiple Embryo Transfers,”Fertility and Sterility 69,pp. 84-88, 1998; published by Elsevier Science, New York.
D. Gardner, “Development of Serum-Free Media for the Culture and Transfer of Human Blastocysts,”Human Repro 13,pp. 101-108, 1998; published by Oxford Univ. Press, Oxford.
Gardner et al., “Elimination of High-Order, Multiple Gestations by Blastocyst Culture and Transfer,”Female Infertility Therapy: Current Practice,Z. Shoham et al., eds., pp. 267-274, 1998; published by Martin Dunnitz, London.
D. Gardner, “Improving Embryo Culture and Enhancing Pregnancy Rate,”Female Infertility Therapy: Current Practice,Z. Shoham et al., eds., pp. 283-299, 1998; published by Martin Dunnitz, London.
Gardner et al., “Human Embryo Viability: What Determines Developmental Potential, and Can It Be Assessed?,”J Assisted Repro&Genetics 15,pp. 455-458, 1998; published by Kluwer, New York.
D. Gardner, “Changes in Requirements and Utilization of Nutrients During Mammalian Preimplantation Embryo Development and Their Significance in Embryo Culture,”Theriogenology 49,pp. 83-102, 1998; published by Elsevier Science, New York.
Gardner et al., “C

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