Methods for improving uniformity of silica films on substrates

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427 2, 4273977, 428446, 604403, 604408, A01N 102, B05D 302, B32B 904

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active

044205171

ABSTRACT:
A process is provided for enhancing the uniformity of silica coatings on substrates, such as evacuated blood collection tubes for example, which increased uniformity results in a substantial increase in the active surface area of the silica for improved clot activation. The process includes hydrolyzing a mixture of ethylsilicate and isopropyl alcohol in the presence of an acid or alkaline solution to precipitate out the silica. The silica sol which results is applied to the substrate, and dried in the presence of low heat application. Alternatively, the silica sol may be mixed with a water soluble carrier such as polyvinyl pyrrolidone, if desired, prior to application to the substrate, if the silica is to be released into a water based substance, such as blood, for example subsequently introduced into the coated container.

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Properties and Applications of Oxide Layers Deposited on Glass from Organic Solutions, H. Schroeder, Oct. 20. 1961.
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