Methods for improved targeting of antibody, antibody fragments,

Details Methods for improved targeting of antibody, antibody fragments, Methods for improved targeting of antibody, antibody fragments,

1987-10-09

1991-07-23

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 8591, 424 11, 514885, A61K 39395, A61K 3944

Patent

active

050342231

ABSTRACT:
Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for a population of cells of a mammal comprises steps of administering to said mammal an adequate dosage of blocking antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, and administering to said mammal an effective dosage of said antibodies or fragments thereof or other receptor-mediated delivery system, such as peptide, specific for said population of cells. In the preferred embodiment, the specific antibodies are monoclonal antibodies directed toward tumor-associated antigen in man.

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patent: 4454106 (1984-06-01), Gansow et al.
patent: 4624846 (1986-11-01), Goldberg
patent: 4676980 (1987-01-01), Segal et al.
patent: 4681760 (1987-07-01), Fathman
patent: 4689311 (1987-08-01), Weltman
patent: 4731244 (1988-03-01), Talle et al.
patent: 4797475 (1989-01-01), Terasaki et al.
patent: 4921690 (1990-05-01), Beatty et al.
Tagliahue et al, Hybridoma 5(2) 1986, pp. 107-115.

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