X-ray or gamma ray systems or devices – Specific application – Absorption
Reexamination Certificate
2007-03-20
2007-03-20
Glick, Edward J. (Department: 2882)
X-ray or gamma ray systems or devices
Specific application
Absorption
C378S064000
Reexamination Certificate
active
11054001
ABSTRACT:
A method of performing radiation therapy includes delivering a therapeutic dose such as X-ray only to a target (e.g., tumor) with continuous broad beam (or in-effect continuous) using arrays of parallel planes of radiation (microbeams/microplanar beams). Microbeams spare normal tissues, and when interlaced at a tumor, form a broad-beam for tumor ablation. Bidirectional interlaced microbeam radiation therapy (BIMRT) uses two orthogonal arrays with inter-beam spacing equal to beam thickness. Multidirectional interlaced MRT (MIMRT) includes irradiations of arrays from several angles, which interleave at the target. Contrast agents, such as tungsten and gold, are administered to preferentially increase the target dose relative to the dose in normal tissue. Lighter elements, such as iodine and gadolinium, are used as scattering agents in conjunction with non-interleaving geometries of array(s) (e.g., unidirectional or cross-fired (intersecting) to generate a broad beam effect only within the target by preferentially increasing the valley dose within the tumor.
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Dilmanian F. Avraham
Hainfeld James F.
Morris Gerard M.
Brookhaven Science Associates LLC
Corbett John M.
Glick Edward J.
Neiger Lori-Anne
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