Methods for imaging atherosclerotic plaque

Details Methods for imaging atherosclerotic plaque Methods for imaging atherosclerotic plaque

1989-04-06

1991-06-25

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, A61K 4902

Patent

active

050265377

ABSTRACT:
This invention pertains to a method of imaging atherosclerotic plaque using radiolabeled monoclonal antibodies that are specific for activated platelets or activated endothelial cells. The method is capable of determining the site of endothelial injury. This method involves the administration of a platelet-specific labeled monoclonal antibody or antibody fragment to a patient. The antibody is allowed to accumulate at the plaque site and the plaque is then scanned with a photoscanner. The detected signals are then converted into an image of the plaque.

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McEver and Martin, J. Biol. Chem. 259:9799-9804 (1984).
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