Chemistry: molecular biology and microbiology – Condition responsive control process
Reexamination Certificate
2005-09-13
2005-09-13
Celsa, Bennett (Department: 1639)
Chemistry: molecular biology and microbiology
Condition responsive control process
C435S808000, C436S063000, C436S164000, C436S172000, C436S182000, C436S800000, C436S805000
Reexamination Certificate
active
06942963
ABSTRACT:
The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a β-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates.
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Blanchard Barbara J.
Ingram Vernon M.
Celsa Bennett
Massachusetts Institute of Technology
Wolf Greenfield & Sacks P.C.
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