Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2007-03-27
2007-03-27
Angell, Jon E. (Department: 1635)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S008000
Reexamination Certificate
active
09860113
ABSTRACT:
The present invention identifies a p53 homolog gene, cep-1, and mutations thereof in the nematodeC. eleganswhich allows for the application of molecular genetic methods to identify new components of the p53 pathway as well as genes that act in parallel to the p53 pathway. cep-1 mutants show elevated physiological germ cell death during normal development. The present invention also provides a simple system with which to perform high-throughput screens for pharmacological agents that suppress the effects of eliminating the cep-1 gene or that enhance its effectiveness when in a mutant state. This strategy should identify agents that selectively kill p53-deficient cells that are resistant to traditional chemotherapeutic regimens and thus block the formation of human tumors that arise when p53 function is compromised.
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Derry William Brent
Rothman Joel H.
Angell Jon E.
Aston David J.
Peters Verny LLP
The Regents of the University of California
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