Methods for identifying novel nucleic acid regulatory...

Details Methods for identifying novel nucleic acid regulatory... Methods for identifying novel nucleic acid regulatory...

2006-07-18

2006-07-18

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S029000, C435S455000

Reexamination Certificate

active

07078171

ABSTRACT:
Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.

REFERENCES:
patent: 5641675 (1997-06-01), Singer et al.
patent: 5773246 (1998-06-01), Keene et al.
patent: 5859227 (1999-01-01), Giordano et al.
patent: 5968738 (1999-10-01), Anderson et al.
patent: 5985575 (1999-11-01), Wickens et al.
patent: 6083727 (2000-07-01), Guegler et al.
patent: WO 94/23041 (1994-10-01), None
patent: WO 98/04923 (1998-02-01), None
patent: WO 98/42854 (1998-10-01), None
patent: WO 98/55502 (1998-12-01), None
Brewer, “An A + U-Rich Element RNA-Binding Factor Regulates c-myc mRNA Stability In Vitro,” Mol. Cell. Biol. 11:2460-2466 (1991).
Carrier et al., “Library of Synthetic 5′ Secondary Structures To Manipulate mRNA Stability inEscherichia Coli,” Biotechnol. Prog. 15:58-64 (1999).
Claffey, et al., “Identification of a Human VPF/VEGF 3′ Untranslated Region Mediating Hypoxia-induced mRNA Stability,” Molecular Biology of the Cell 9:469-481 (1998).
Donis-Keller et al., “Site Specific Enzymatic Cleavage of RNA,” Nucl. Acids Res. 7:179-192 (1979).
Gao et al., “Selection of a Subset of mRNAs from Combinatorial 3′ Untranslated Region Libraries Using Neuronal RNA-binding Protein He1-N1,” PNAS USA 91:11207-11211 (1994).
Goldspink et al., “Localization of Cardiac α-myosin Heavy Chain mRNA is Regulated by its 3′ Untranslated Region Via Mechanical Activity And Translational Block,” Journal of Cell Science 110:2969-2978 (1997).
Grignani et al., “High-Efficiency Gene Transfer and Selection of Human Hematopoietic Progenitor Cells with a Hybrid EBV/Retroviral Vector Expressing the Green Fluorescence Protein,” Cancer Res. 58:14-19 (1998).
Ho, et al., “Use of a Marked Erythropoietin Gene for Investigation of Its Cis-acting Elements,” J. Biol. Chem. 270:10084-10090 (1995).
Izquierdo et al., “Control of the Translational Efficiency of β-F1-ATPase mRNA Depends on the Regulation of a Protein That Binds the 3′ Untranslated Region of the mRNA,” Molecular And Cellular Biology 17(9):5255-5268 (1997).
Kozak et al., “An Analysis of 5′-Noncoding Sequences from 699 Vertebrate Messenger RNAs,” Nucl. Acids Res. 15:8125-8148 (1987).
Menotti et al., “Translational Regulation of mRNAs With Distinct IRE Sequences by Iron Regulatory Proteins 1 and 2,” J. Biol. Chem. 273(3):1821-1824 (1998).
Müllner et al., “A Specific mRNA Binding Factor Regulates the Iron-Dependent Stability of Cytoplasmic Transferrin Receptor mRNA,” Cell 58:373-382 (1989).
Nakanishi et al., “Reduction of Syndecan-1 mRNA in Cervical-carcinoma Cells is Involved With the 3′ Untranslated Region,” Int. J. Cancer 80(4):527-532 (1999).
Ohlmann et al., “The Properties of Chimeric Picornavirus IRESes Show That Discrimination Between Internal Translation Initiation Sites Is Influenced by the Identity of the IRES and Not Just the Context of the AUG Codon,” RNA 5:764-778 (1999).
Romeo et al., “An Element of the Transforming Growth Factor-beta 1 5′-untranslated Region Represses Translation and Specifically Binds a Cytosolic Factor,” Mol. Endocrinol. 7(6):759-766 (1993).
Sharp et al., “Regulation of Chicken α and β Actin Genes And Their Hybrids Inserted Into Myogenic Mouse Cells,” Gene 80:293-304 (1989).
Shaw et al., “A Conserved AU Sequence from the 3′ Untranslated Region of GM-CSF mRNA Mediates Selective mRNA Degradation,” Cell 46:659-666 (1986).
Spicher et al., “Highly Conserved RNA Sequences That Are Sensors of Environmental Stress,” Molecular and Cellular Biology, 18:7371-7382 (1998).
Suzuki et al., “Construction And Characterization Of A Full Length-enriched And A 5′-end-enriched cDNA Library,” Gene 200:149-156 (1997).
Yang et al., “The 3′-Untranslated Region of the α2c-Adrenergic Receptor mRNA Impedes Translation of the Receptor Message,” J. Biol. Chem. 272:15466-15473 (1997).
Wilson et al., “An Episomal Expression Vector System For Monitoring Sequence-specific Effects on mRNA Stability in Human Cell Lines,” Plasmid 33(3):198-207 (1995).
Zaidi et al., “Amyloid Precursor Protein mRNA Stability Is Controlled by a 29-Base Element in the 3′-Untranslated Region,” J. Biol. Chem. 269:24007-24013 (1994).

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