Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-11-18
1999-01-05
Teng, Sally P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 15, 435 21, 435194, 435196, 435 691, 435325, 536 235, C12Q 100, C12N 1552, C12N 510
Patent
active
058561110
ABSTRACT:
The present invention relates to cell lines useful for the screening and identification of compounds that by modulating phosphotyrosine phosphatase activity, modulate insulin receptor type tyrosine kinase mediated signal transduction. Genetically engineered cells expressing IR in culture overcome the effect of insulin on morphology and adhesion when they are also coexpressing RPTP.alpha. or RPTP.epsilon.. Such engineered cell lines may be used to screen and identify non-toxic compounds that could elicit or modulate insulin signal transduction even in the absence of insulin.
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Hoppe Edmund
M.o slashed.ller Niels Peter Hundahl
Ullrich Axel
Max-Planck-Gessellschaft Zur Forderung der Wissenschaften E.V.
Teng Sally P.
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