Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-30
1997-11-04
Walsh, Stephen
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 721, 4352401, 4352402, 530350, 530399, 530395, 536 231, 536 235, G01N 3353, C12N 1512, C12N 1563, C07K 1472
Patent
active
056838840
ABSTRACT:
Human calcitonin receptors have been cloned, sequenced and expressed by recombinant means. The receptors and antibodies thereto may be used in screening systems to identify agonists and antagonists of human calcitonin receptors, thereby providing means for treating and preventing abnormal bone resorption, as well as in methods of diagnosis.
REFERENCES:
patent: 5516651 (1996-05-01), Goldring et al.
Chovev, M. et al. J. Bone and Mineral Res. 1992 (Aug) vol. 7, Supp. l p. 5243.
Lin, H. T. et al. Science (1991) vol. 254:pp. 1022-1024.
Goldring, S.R. et al. Horm. Metab. Res (1993) vol. 25: 477-480.
Chabre, O. et al. Mol Endocrihol (1992) 6: 551-556.
Hendry et al., "Immobilization of Antibodies of Nylon for Use in Enzyme-Linked Immunoassay", J. Immunol. Meths. 35:285-296 (1980).
Moseley et al., "The Calcitonin Receptor On T 47D Breast Cancer Cells", Biochem, J., 212:609-616 (1983).
Bouizar et al., "Purification and Characterization of Calcitonin Receptors in Rat Kidney Membranes by Covalent Cross-Linking Techniques", Eur. J. Biochem, 155:141-147 (1986).
Sambrook et al., "Synthetic Oligonucleotide Probes", Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY, pp. 11.2-11.60 (1989).
Libert et al., "Selective Amplification and Cloning of Four New Members of the G Protein-Coupled Receptor Family" Science 244:569-572 (May 5, 1989).
Tsai-Morris et al., "Intronic Nature of the Rat Luteinizing Hormone Receptor Gene Defines a Soluble Receptor Subspecies with Hormone Binding Activity", J. Biol. Chem. 265:19385-19388 (Nov., 1990).
Raue et al., "The Calcitonin Receptor: Characterization and Processing", Molecular and Cellular Regulation of Calcium and Phosphate Metabolism, p. 67-69 (1990).
Lam et al., "A New Type of Synthetic Peptide Library for Identifying Ligand-Binding Activity", Nature 354:82-84 (Nov. 9, 1991).
Lin et al., "Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor", Science, 254:1022-1024 (Nov. 15, 1991).
Juppner et al., "A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide", Science, 254:1024-1026 (Nov. 15, 1991).
Lin et al., "Expression Cloning and Characterization of a Porcine Renal Calcitonin Receptor", Trans. Assoc. Am. Physicians 104:265-272 (1991).
Stern, P. S., "Predicting Antigenic Sites on Proteins," Tibtech. 9:163-68 (1991).
Chabre et al., "A Recombinant Calcitonin Receptor Independently Stimulates 3', 5'-Cyclic Adenosine Monophosphate and Ca.sup.2+ Inositol Phosphate Signaling Pathways", Molecular Endocrinology, 6(4): 551-556 (1992).
Goldring, "Characterization of a Porcine renal Calcitonin Receptor; Comparison to Other G Protein-Coupled Receptors", Bone and Mineral, Abst. 81:42 (1992).
Gorn et al., "Properties of a Calcitonin Receptor Cloned from Human Ovarian Carcinoma Cell", Bone and Mineral, Abst., 81:43 (1992).
Muff, et al., "Comparison of a Calcitonin Gene-Related Peptide Receptor in a Human Neuroblastoma Cell Line (SK-N-MC) and a Calcitonin Receptor in a Human Breast Carcinoma Cell Line (T47D).sup.a ", New York Academy of Sciences, 657:106-116 (1992).
Quirion, et al., "Characterization of CGRP.sub.1 and CGRP.sub.2 Receptor Subtypes.sup.a " New York Academy of Sciences, 657:88-105 (1992).
Moore et al., "The Cloned Human Calcitonin Receptor Can Couple to Two Alternative Second Messenger Pathways When Expressed in BHK Cells", J. Bone Miner. Res., Abst., S146:215 (Aug., 1992).
Gorn et al., "Cloning, Characterization, and Expression of a Human Calcitonin Receptor from an Ovarian Carcinoma Cell Line", J. Clin. Invest. 90:1726-1735 (Nov., 1992).
Chabre et al., "A Recombinant Calcitonin Receptor Independently Stimulates 3', 5'-Cyclic Adenosine Monophosphate and Ca.sup.2+ /Inositol Phosphate Signaling Pathways" Mol. Endo. 6:551-556 (1992).
Force et al., "A Cloned Porcine Renal Calcinonin Receptor Couples to Adenylyl Cyclase and Phospholipase C", Am. J. Physiol. 262:F1110-F1115 (1992).
Iismaa et al. "G Protein-Coupled Receptors", Curr. Opin. Cell Biol. 4:195-202 (1992).
Albrandt et al., "Molecular Cloning of Two Receptors from Rat Brain with High Affinity for Salmon Calcitonin", FEBS Lett. 325:225-232 (1993).
Yamin et al., "Analysis of a Unique Murine Brain Calcitonin Receptor (CTR) cDNA and Preliminary Characterization of the Murine CTR Gene; Evidence for the Existence of Functionally Distinct Isoforms of the CTR", J. Bone. Mineral Res., 8 (Supp. 1) p. S129, Abst. 51 (Aug., 1993).
Houssami et al., "Rat Calcitonin Receptor Isoforms Display Functional Heterogeneity", J. Bone. Mineral Res., 8 (Supp. 1) p. S129, Abst. 52 (Aug., 1993).
Gorn et al., "The Cloning of a Human Osteoclast Calcitonin Receptor From A Giant Cell Tumor of Bone (Osteoclastoma)", J. Bone. Mineral Res., 8 (Supp. 1) p. S384, Abst. 1069 (Aug., 1993).
Sexton et al. "Identification of Brain Isoforms of the Rat Calcitonin Receptor", Mol. Endo. 7:815-821 (1993).
Nussenzveig et al., "Inhibition of Inositol Phosphate Second Messenger Formation by Intracellular Loop One of a Human Calcitonin Receptor," J. Biol. Chem., 269:28123-28129 (Nov., 1994).
Kuestner Rolf E.
Moore Emma E.
Sheppard Paul O.
Basham Daryl A.
Walsh Stephen
ZymoGenetics Inc.
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