Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...
Reexamination Certificate
2003-06-05
2008-12-30
Gakh, Yelena G (Department: 1797)
Chemistry: analytical and immunological testing
Nuclear magnetic resonance, electron spin resonance or other...
Reexamination Certificate
active
07470543
ABSTRACT:
A method of identifying a ligand to a target molecule that includes: providing a reference compound that interacts with the target molecule; collecting a 1D1H nuclear magnetic resonance spectrum of the reference compound in the presence of the target molecule; providing a plurality of test samples, each test sample including at least one test compound; collecting a 1D1H nuclear magnetic resonance spectrum of the reference compound in the presence of each test sample and the target molecule; comparing the spectrum of the reference compound in the presence of the target molecule to the spectrum of the reference compound in the presence of each test sample and the target molecule to determine a change in one or more of the reference compound resonances; and identifying at least one test compound that interacts with the target molecule, wherein the test compound displaces the reference compound.
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Dalvit Claudio
Stockman Brian J
Gakh Yelena G
Nerviano Medical Sciences S.r.l.
Scully , Scott, Murphy & Presser, P.C.
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