Methods for identifying inhibitors of the 20S and 26S...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007910, C435S007710

Reexamination Certificate

active

07601512

ABSTRACT:
The present invention relates to methods for identifying fungicides and also inhibitors of the 20S and 26S proteasomes, to methods for isolating 20S proteasomes, to the use of 20S proteasomes for identifying fungicides and to the use of the inhibitors of 26S and/or 20S proteasomes as fungicides.

REFERENCES:
patent: 5425942 (1995-06-01), Tanaka
patent: 5693617 (1997-12-01), Stein et al.
patent: 6613541 (2003-09-01), Vaddi et al.
patent: 2077665 (1991-09-01), None
patent: 2 359 561 (2001-07-01), None
patent: 5-292964 (1993-11-01), None
patent: 6-22759 (1994-02-01), None
patent: 98/42829 (1998-10-01), None
patent: WO 00/23614 (2000-04-01), None
Science, vol. 268, May 5, 1995, pp. 726-731, “Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin” by G. Fenteany et al.
Nature, 386, Apr. 3, 1997, pp. 463-471, “Structure of 20S proteasome from yeast at 2.4 Å resolution” by M. Groll et al.
Journal of Biomolecular Screening, vol. 4, No. 2, (month unavailable) 1999, pp. 67-73, “A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays” by Ji-Hu Zhang et al.
Chem. Biol. 5, (month unavailable) 1998, pp. 307-320, “Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes” by M. Bogyo et al.
Annu. Rev. Biochem., 65, (month unavailable) 1996, pp. 801-847, “Structure And Functions Of The 20S and 26S Proteasomes” by O. Coux et al.
J. Biol. Chem., 273 (15), Apr. 10, 1998, pp. 8820-8828, “Enzymes Catalyzing Ubiquitination and Proteolytic Processing of the p105 Precursor of Nuclear Factor κB1” by O. Coux et al.
J. Biol. Chem., 265, Mar. 25, 1990, pp. 4789-4792, “The Proteasome (Multicatalytic Protease) Is a Component of the 1500-kDa Proteolytic Complex Which Degrades Ubiquitin-conjugated Proteins” by J. Driscoll et al.
Proc. Natl. Acad. Sci. USA, vol. 96, pp. 10403-10408, Aug. 1999, “Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity” by L. Meng et al.
Bioscene, 26 (3), (month unavailable) 2000, pp. 9-13, “Modeling Antimicrobial Activity of Clorox™ Using an Agar-Diffusion Test: A New Twist on an Old Experiment” by J. K. Mitchell et al.
Biochemistry, (month unavailable) 1993, 32, pp. 1563-1572, “Evidence for the Presence of Five Distinct Proteolytic Components in the Pituitary Multicatalytic Proteinase Complex. Properties of Two Components Cleaving Bonds on the Carboxyl Side of Branched Chain and Small Neutral Amino Acids” by M. Orlowski et al.
Cell, vol. 60, pp. 295-306, Jan. 26, 1990, “ThebAlleles ofU. maydis, Whose Combinations Program Pathogenic Development, Code for Polypeptides Containing a Homeodomain-Related Motif” by B. Schulz et al.
Nature Biotechnology, Dec. 18, 2000, pp. 1298-1302, “A ubiquitin-based tagging system for Controlled modulation of protein stability” by J. H. Stack et al.
Biochemistry, (month unavailable) 1996, 35, pp. 3899-3908, “Kinetic Characterization of the Chymotrypic Activiity of the 20S Proteasome” by R. L. Stein et al.
Neuroscience Letters, 201, (month unavailable) 1995, pp. 29-32, “Calpain inhibitor I decreases βA4 secretion from human embyonal kidney cells expressing β-amyloid precursor protein carrying the APP670/671 double mutation” by Hans-W. Klafki et al.
Nature, 390, Dec. 1997, pp. 639-643, “Structure of the proteasome activator REGα (PA28α)” by J. Randolph Knowlton et al.
Chem Biol., 6, (month unavailable) 1999, pp. 689-698, “The secondary fungal metabolite Gliotoxin targets proteolytic activities of the proteasome” by M. Kroll et al.
Molecular And Cellular Biology, vol. 18, Jan. 1998, pp. 30-38, “Proteasome Inhibitors Cause Induction of Heat Schock Proteins and Trehalose, Which Together Confer Thermotolerance inSaccharomyces cerevisiae” by Do Hee Lee et al.
The Journal Of Biological Chemistry, vol. 271, No. 44, Issue of Nov. 1, 1996, pp. 27280-27284, “Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation inSaccharomyces cerevisiae” by Do Hee Lee et al.
The Journal Of Biological Chemistry, vol. 272, No. 47, Issue of Nov. 21, 1997, pp. 29899-29903, “Specificities of Cell Permeant Peptidyl Inhibitors for the Proteinase Activities of μ-Calpain and the 20 S Proteasome” by R. L. Mellgren.
Biochemistry, (month unavailable) 1998, pp. 7792-7800, “Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes andclasto-Lactacystin β-Lactone” by T. A. McCormack et al.
Jones R. W. et al: “Variation in Sensitivity Among Anastomosis Groups of Rhizoctonia-Solani To The Antibiotic Gliotoxin” Plant Disease, Bd. 71, Nr. 1, 1987, Seiten 34-36, XP009019179 ISSN: 0191-2917 das ganze Dokument.
Saeki Yasushi et al: “Rapid isolation and characterization of the yeast proteasome regulatory complex” Biochemical and Biophysical Research Communications, Bd. 273, Nr. 2, Jul. 5, 2000, Seiten 509-515, XP002268381.
Emmerlich Vera et al: “Isolation and subunit composition of the 20S proteasome ofGiardia lamblia” Molecular and Biochemical Parasitology, Bd. 100, Nr. 1, May 15, 1999, Seiten 131-134, XP002268382.
Hori Hiroshi et al: “Isolation and characterization of two 20S proteasomes from the endoplasmic reticulum of rat liver microsomes” Journal of Biochemistry (Tokyo), Bd. 126, Nr. 4, Oct. 1999, Seiten 722-730, XP009019175.
Furet P. et al: “Modeling of the Binding Mode of a Non-Covalent Inhibitor of the 20S Proteasome. Applications to Structure-Based Analogue Design” Bioorganic & Medicinal Chemistry Letters, Oxford, GB, Bd. 11, Nr. 10, May 21, 2004, Seiten 1321-1324, XP001059888.
Koguchi Y. et al: “TMC-95A, B, C and D, Novel Proteasome Inhibitors Produced by Apiospora Montagnei Sacc. TC 1093 Taxonomy, Production, Isolation and Biological Activities” Journal of Antibiotics, Japan Antibiotics Research Association. Tokyo, JP, Bd. 53, Nr. 2, Feb. 2000, Seiten 105-109, XP002953124.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for identifying inhibitors of the 20S and 26S... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying inhibitors of the 20S and 26S..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying inhibitors of the 20S and 26S... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4062979

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.