Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-03-14
1996-06-04
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 78, 436501, G01N 3353
Patent
active
055232094
ABSTRACT:
The invention features a method for inhibiting the ligand binding of an integrin in a cell involving introducing into the cell a compound which inhibits integrin activation, a method for identifying compounds which inhibit integrin activation, and chimeric integrin molecules.
REFERENCES:
patent: 4981784 (1991-01-01), Evans et al.
patent: 5030576 (1991-07-01), Dull et al.
Adams, et al., Changes in Keratinocyte Adhesion During Terminal Differentiation: Reduction in Fibronectin Binding Precedes .alpha..sub.5 .beta..sub.1 Integrin Loss from the Cell Surface, Cell 63:425-435 (1990).
Albelda, et al., Integrins and other cell adhesion molecules, FASEB, J. 4:2868-2880 (1990).
Altieri, Occupancy of CD11b/CD18 (Mac-1) Divalent Ion Binding Site(s) Induces Leukocyte Adhesion, The Journal of Immunology 147:1891-1898 (1991).
Altieri, et al., Oligospecificity of the Cellular Adhesion Receptor MAC-1 Encompasses an Inducible Recognition Specificity for Fibrinogen, The Journal of Cell Biology 107:1893-1900 (1988).
Bennett, et al., Exposure of Platelet Fibrinogen Receptors by ADP and Epinephrine, J. Clin. Invest. 64:1393-1401 (1979).
Bennett, et al., Interaction of Fibrinogen with Its Platelet Receptor, The Journal of Biological Chemistry 263:12948-12953 (1988).
Bosco, et al., Multiple Functional Forms of the Integrin VLA-2 Can be Derived from a Single .alpha..sup.2 cDNA Clone: Interconversion of Forms . . . The Journal of Cell Biology 120:537-543 (1993).
Burger, et al., Induced Cell Surface Expression of Functional .alpha..sub.2 .beta..sub.1 Integrin during Megakaryocytic Differentiation of K562 Leukemic Cells, Experimental Cell Research 201:28-35 (1992).
Conforti, et al., Modulation of Vitronectin Receptor Binding by Membrane Lipid Composition, The Journal of Biological Chemistry 265:4011-4019 (1990).
Danilov, et al., Phorbol Ester Modulation of Integrin-mediated Cell Adhesion: A Postreceptor Event, The Journal of Cell Biology 108:1925-1933 (1989).
Du, et al., Ligands "Activate" Integrin .alpha..sub.IIb .beta..sub.3 (Platelet GPIIb-IIIa), Cell 65:409-416 (1991).
Dustin, et al., Regulation of Locomotion and Cell-Cell Contact Area by the LFA-1 and ICAM-1 Adhesion Receptors, The Journal of Immunology 148:2654-2663 (1992).
Elices, et al., The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others, Proc. Natl. Acad. Sci. USA 86:9906-9910 (1989).
Faull, et al., Affinity Modulation of Integrin .alpha.5.beta.1: Regulation of the Functional Response by Soluble Fibronectin, The Journal of Cell Biology 121:155-162 (1993).
Frelinger, et al., Monoclonal Antibodies to Ligand-occupied Comformers of Integrin .alpha..sub.IIb .beta..sub.3 (Glycoprotein IIb-IIIa) Alter . . . The Journal of Biological Chemistry 266:17106-17111 (1991).
Frelinger, et al., Selective Inhibition of Integrin Function by Antibodies Specific for Ligand-occupied Receptor Conformers, The Journal of Biological Chemistry 265:6346-6352 (1990).
Gailit, et al., Regulation of the Fibronectin Receptor Affinity by Divalent Cations, The Journal of Biological Chemistry 263:12927-12932 (1988).
Ginsberg, et al., The Mechanism of Thrombin-Induced Platelet Factor 4 Secretion, Blood 55:661-668 (1980).
Ginsberg, et al., Inside-out Integrin signaling, Current Opinion in Cell Biology 4:766-771 (1992).
Grant, et al., Effects of Chymotrypsin on the Release Reaction and Aggregation of Blood Platelets, Proceedings of the Society for Experimental Biology and Medicine 165:114-117 (1980).
Hemler, VLA Proteins in the Integrin Family, Structures, Functions, and Their Role on Leukocytes, Annu. Rev. Immunol. 8:365-400 (1990).
Hermanowski-Vosatka, et al., Integrin Modulating Factor-1: A Lipid That Alters the Function of Leukocyte Integrins, Cell 68:341-352 (1992).
Hynes, Integrins: Versatility, Modulation, and Signaling in Cell Adhesion, Cell 69:11-25 (1992).
Hynes, et al., Integrin Heterodimer and Receptor Complexity in Avian and Mammalian Cells, The Journal of Cell Biology, 109:409-420 (1989).
Kirchhofer, et al., Cation-dependent Changes in the Binding Specificity of the Platelet Receptor GPIIb/IIIa, The Journal of Biological Chemistry 265:18525-18530 (1990).
Kovach, et al., A Monoclonal Antibody to .beta..sub.1 Integrin (CD29) Stimulates VLA-dependent Adherence of Leukocytes to Human Umbilical Vein . . . The Journal of Cell Biology 116:499-509 (1992).
Kunkel, Rapid and efficient site-specific mutagenesis without phenotypic selection, Proc. Natl. Acad. Sci. USA 82:488 -492 (1985).
Loftus, et al., A .beta..sub.3 Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation, Science 249:915-918 (1990).
Masumoto et al, Multiple Activation States of VLA-4, The Journal of Biological Chemistry 268:228-234 (1993).
Munson, et al., Ligand: Versatile Computerized Approach for Characterization of Ligand-Binding Systems, Analytical Biochemistry 107:220-239 (1980).
Neugebauer, et al., Cell-surface regulation of .beta..sub.1 -integrin activity on developing retinal neurons, Nature 350:68-71 (1991).
O'Toole, et al., Modulation of the Affinity of Integrin .alpha..sub.IIb .beta..sub.3 GPIIb-IIIa) by the Cytoplasmic Domain of .alpha..sub.IIb, Science 254:845-847 (1991).
O'Toole, et al., Affinity modulation of the .alpha..sub.IIb .beta..sub.3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor, Cell Regulation 1:883t14 893 (1990).
O'Toole, et al., Efficient Surface Expression of Platelet GPIIb-IIIa Requires Both Subunits, Blood 74:14-18 (1989).
Plow, et al., Related Binding Mechanisms for Fibrinogen, Fibronectin, von Willebrand Factor, and Thrombospondin on Thrombin-Stimulated Human Platelets, Blood 66:724-727 (1985).
Ruoslahti, Integrins, J. Clinical Investigation 87:1-5 (1991).
Smyth, et al., Fibrinogen Binding to Purified Platelet Glycoprotein IIb-IIIa (Integrin .alpha..sub.IIb .beta..sub.3 is Modulated by Lipids, The Journal of Biological Chemistry 267:15568-15577 (1992).
Springer, Adhesion receptors of the immune system, Nature 346:425-434 (1990).
Weitzman, et al., The Function and Distinctive Regulation of the Integrin VLA-3 in Cell Adhesion, Spreading, and Homotypic Cell Aggregation, The journal of Biological Chemistry 268:8651-8657 (1993).
Werb, et al., Signal Transduction through the Fibronectin Receptor Induces Collagenase and Stromelysin Gene Expression, The Journal of Cell Biology 109:877-889 (1989).
Ylanne, et al., Distinct Functions of Integrin .alpha. and .beta. Subunit Cytoplasmic Domains in Cell Spreading and Formation of Focal Adhesions, The Journal of Cell Biology 122:223-233 (1993).
Zucker, et al., Platelet Activation, Arteriosclerosis 5:2-18 (1985).
O'Toole et al, J. Cell Biol. 124 1047-1059 (1994).
Picker et al, Eur. J. Immunol. 23 2751-2757 (1993).
Ginsberg Mark H.
O'Toole Timothy E.
Brown Karen E.
Draper Garnette D.
The Scripps Research Institute
LandOfFree
Methods for identifying inhibitors of integrin activation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for identifying inhibitors of integrin activation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying inhibitors of integrin activation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-382615