Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-02-28
2006-02-28
Tate, Christopher R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S329000, C435S006120, C435S007100, C424S085100
Reexamination Certificate
active
07005419
ABSTRACT:
The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability of Cdc2/cyclin B1 complexes to cause a pause at the G2/M stage of the cell cycle in response to GADD45, and nucleic acids which encode such polypeptides.
REFERENCES:
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Richards, S.A. et al., “The C terminus of the nuclear RAN/TC4 GTPase stabilizes the GDP-bound state and mediates interactions with RCC, RAN-GAP and HTF9A/RANBP1,” Journal of Biological Chemistry, 1995, pp. 14405-14411, vol. 270(24).
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Yang, Q. et al., “Mechanisms of a GADD45-mediated G2/M checkpoint,” AACR special conference, Genetic and Fuctional Consequences of Cell Cycle Alteration in Cancer, Oct. 20-24, 1999, San Diego, California, USA.
Zhan, Q. et al., “Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinese activity by the p53-regulated protein Gadd45,” Oncogene, 1999, pp. 2892-2900, vol. 18.
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Coursen Jill D.
Fornace, Jr. Albert J.
Harris Curtis C.
Wang Xin Wei
Zhan Qimin
Chism B. Dell
Tate Christopher R.
The United States of America as represented by the Department of
Townsend and Townsend / and Crew LLP
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