Methods for identifying iminosugar derivatives that inhibit...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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C435S235100

Reexamination Certificate

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10669175

ABSTRACT:
Disclosed are methods for screening that may be used to identify an inhibitor of HCV p7 protein. The methods may include incorporating an HCV p7 protein into a membrane to create an HCV p7-containing membrane that has an increased permeability relative to a membrane that does not contain HCV p7 protein. The HCV p7 protein may be contacted with a test compound, and the permeability of this HCV p7-containing membrane then may be compared to an HCV p7-containing membrane in which the HCV p7 protein has not been contacted with the test compound. The inhibitor of HCV p7 protein may be identified by observing a decrease in the permeability of the HCV p7-containing membrane in which the HCV p7 protein has been contacted with the test compound.

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