Methods for identifying factors for differentiating...

Details Methods for identifying factors for differentiating... Methods for identifying factors for differentiating...

2005-06-23

2009-06-02

Ton, Thaian N. (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S004000

Reexamination Certificate

active

07541185

ABSTRACT:
Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.

REFERENCES:
patent: 5453357 (1995-09-01), Hogan
patent: 5670372 (1997-09-01), Hogan
patent: 5690926 (1997-11-01), Hogan
patent: 5817637 (1998-10-01), Weiner et al.
patent: 5830876 (1998-11-01), Weiner et al.
patent: 5843780 (1998-12-01), Thomson
patent: 6015671 (2000-01-01), Field
patent: 6090622 (2000-07-01), Gearhart et al.
patent: 6165993 (2000-12-01), Herrmann et al.
patent: 6200806 (2001-03-01), Thomson
patent: 6251671 (2001-06-01), Hogan et al.
patent: 6261281 (2001-07-01), Mathiesen et al.
patent: 6458589 (2002-10-01), Rambhatla et al.
patent: 6506574 (2003-01-01), Rambhatla et al.
patent: 6872389 (2005-03-01), Faris
patent: 6921811 (2005-07-01), Zamora et al.
patent: 7033831 (2006-04-01), Fisk et al.
patent: 7256042 (2007-08-01), Rambhatla et al.
patent: 7326572 (2008-02-01), Fisk et al.
patent: 2002/0072117 (2002-06-01), Xu et al.
patent: 2003/0138948 (2003-07-01), Fisk et al.
patent: 2003/0138949 (2003-07-01), Bhushan et al.
patent: 2003/0175956 (2003-09-01), Bodnar et al.
patent: 2003/0190748 (2003-10-01), Thomson
patent: 2003/0224411 (2003-12-01), Stanton et al.
patent: 2004/0127406 (2004-07-01), Presnell et al.
patent: 2004/0229350 (2004-11-01), Strelchenko et al.
patent: 2005/0079159 (2005-04-01), Shastri et al.
patent: 2006/0003446 (2006-01-01), Keller et al.
patent: 2006/0019387 (2006-01-01), Faris
patent: 2006/0040385 (2006-02-01), Itskovitz-Eldor et al.
patent: 2006/0040387 (2006-02-01), Fisk et al.
patent: 2006/0128018 (2006-06-01), Zwaka et al.
patent: 2006/0148081 (2006-07-01), Kelly et al.
patent: 2006/0276420 (2006-12-01), Keller et al.
patent: 2007/0281355 (2007-12-01), Dalton et al.
patent: 1298201 (2003-04-01), None
patent: WO 98/30679 (1998-07-01), None
patent: WO 99/13915 (1999-03-01), None
patent: WO 00/29442 (2000-05-01), None
patent: WO 02/10347 (2002-02-01), None
patent: WO 02/059278 (2002-08-01), None
patent: WO 03/050249 (2003-06-01), None
patent: WO 03/050249 (2003-06-01), None
patent: WO 03/100026 (2003-12-01), None
patent: WO 2004/098490 (2004-11-01), None
patent: WO 2005/017131 (2005-02-01), None
patent: WO 2005/033294 (2005-04-01), None
patent: WO 2005/045001 (2005-05-01), None
patent: WO 2005/063971 (2005-07-01), None
patent: WO 2005/116073 (2005-12-01), None
patent: WO 2006/002919 (2006-02-01), None
patent: WO 2006/016999 (2006-02-01), None
patent: WO 2006/017134 (2006-02-01), None
patent: WO 2006/034873 (2006-04-01), None
patent: WO 2006/083782 (2006-08-01), None
patent: WO 2007/002210 (2007-01-01), None
Collombat et al., Specifying pancreatic endocrine cell fates. Mech Dev. 123(7): 501-12, 2006.
Wilding et al., The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors. Diabetes Metab Res Rev. 20(2):114-23, 2004.
Holland et al. Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A 2002; 99(19): 12 236-12 241.
Gardner, Stem cells and regenerative medicine: principles, prospects and problems. C R Biol. 330(6-7):465-73, 2007.
Dudas et al., The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium, Anat Embryol (Berl). 208(5):359-66, 2004.
Trueba et al. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations. J Clin Endocrinol Metab. Jan. 2005;90(1):455-62, 2005.
Houde et al., Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2. J Biol Chem. 276(24):21885-94, 2001.
Alexander, J., and Stainier, D.Y. (1999). A molecular pathway leading to endoderm formation in zebrafish. Curr Biol 9, 1147-1157.
Alexander, J., Rothenberg, M., Henry, G.L., and Stainier, D.Y. (1999). Casanova plays an early and essential role in endoderm formation in zebrafish. Dev Biol 215, 343-357.
Aoki, T.O., Mathieu, J., Saint-Etienne, L., Rebagliati, M.R., Peurieras, N., and Rosa, F. M. (2002). Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor. Dev Biol 241, 273-288.
Barry et al. (1994). The production of monoclonal antibodies by genetic immunization. Biotechniques 16 : 616-620.
Beck, S., Le Good, J.A., Guzman, M., Ben Haim, N., Roy, K., Beermann, F., and Constam, D.B. (2002). Extra-embryonic proteases regulate Nodal signaling during gastrulation. Nat Cell Biol 4, 981-985.
Beddington, R.S., Rashbass, P., and Wilson, V. (1992). Brachyury—a gene affecting mouse gastrulation and easly organogenesis. Dev Suppl, 157-165.
Bongso, A., Fong, C.Y., Ng, S.C., and Ratnam, S. (1994). Isolation and culture of inner cell mass cells from human blastocysts. Hum Reprod 9, 2110-2117.
Chang, H., Brown, C.W., and Matzuk, M.M (2002). Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23, 787-823.
Conlon, F.L., Lyons, K.M., Takaesu, N., Barth, K.S., Kispert, A., Herrmann, B., and Robertson, E.J. (1994). A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928.
Costaglia et al. (1998) Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J. Immunol. 160: 1458-1465.
Dougan, S.T., Warga, R.M., Kane, D.A., Schier, A.F., and Talbot, W.S. (2003). The role of the zebrafish nodal-related genes squint and Cyclops in patterning of mesendoderm. Development 130, 1837-1851.
Edlund, H., “Factors Controlling Pancreatic Cell Differentiation and Function,” Diabetologia, Sep. 2001, vol. 44, No. 9, pp. 1071-1079.
Falasca, L. et al., “Retinoic Acid Treatment Induces Apoptosis or Expression of a More Differentiated Phenotype on Different Fractions of Cultured Fetal Rat Hepatocytes Hepatology,” 1998, vol. 28, No. 3, pp. 727-737.
Feldman, B., Gates, M.A., Egan, E.S., Dougan, S.T., Rennebeck, G., Sirotkin, H. I., Schier, A.F., and Talbot, W.S. (1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395, 181-185.
Feng, Y., Broder, C.C., Kennedy, P.E., and Berger, E.A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877.
Futaki, S., Hayashi, Y., Yamashita, M., Yagi, K., Bono, H., Hayashizaki, Y., Okazaki, Y., and Sekiguchi, K. (2003). Molecular basis of constitutive production of basement membrane components: Gene expression profiles of engelbreth-holm-swarm tumor and F9 embryonal carcinoma cells. J Biol. Chem.
Grapin-Botton, A., and Melton, D. A. (2000). Endoderm development: from patterning to organogenesis. Trends Genet 16, 124-130.
Hamazaki et al. “Hepatic Maturation in Differentiating Embryonic Stem Cells in Vitro.” Febs Letter, Elsevier Science Publishers, Amsterdam, NL, vol. 497, No. 1: 15-19.
Harris, T. M., and Childs, G. (2002). Global gene expression patterns during differentiation of F9 embryonal carcinoma cells into parietal endoderm. Funct. Integr Geneomics 2, 105-119.
Hogan, B.L. (1996). Bone morphogenetic proteins in development. Curr Opin Genet Dev 6, 432-438.
Howe, C.C., Overton, G.C., Sawicki, J., Solter, D., Stein, P., and Strickland, S. (1988). Expression of SPARC/osteonectin transcript in murine embryos and gonads. Differentiation 37, 20-25.
Hudson, C., Clements, D., Friday, R. V., Stott, D., and Woodland, H.R. (1997). Xsox17alpha and -beta mediate endoderm formation in Xenopus. Cell 91, 397-405.
Imada, M., Imada, S., Iwasaki, H., Kume, A., Yamaguchi, H., and Moore, E.E. (1987). Fetomodulin: Marker surface protein of fetal development which is modulatable by cyclic AMP. Dev Biol 122, 483-491.
Jain, K. et al.,

Affiliated with

Also associated with

Rating

Methods for identifying factors for differentiating... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying factors for differentiating..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying factors for differentiating... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4107988