Methods for identifying compounds that regulate...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C435S194000, C435S195000, C930S240000

Reexamination Certificate

active

07999075

ABSTRACT:
A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.

REFERENCES:
patent: 2005/0181452 (2005-08-01), Westwick et al.
patent: 2006/0026702 (2006-02-01), Rockman et al.
patent: 2006/0029983 (2006-02-01), Oakley et al.
patent: 2006/0188944 (2006-08-01), Barak et al.
Beaulieu JM, Sotnikova TD, Yao WD, Kockeritz L, Woodgett JR, Gainetdinov RR, Caron MG. Lithium antagonized dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proceedings of the National Academy of Sciences 101(14):5099-5104 (2004).
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior. Cell 122:261-273 (2005).
Lefkowitz RJ, Shenoy SK. Transduction of Receptor Signals by β-Arrestins. Science 308:512-517 (2005).
Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP, Spedding M, Harmar AJ. International Union of Pharmacology. XLVI. G Protein-Coupled Receptor List. Pharmacological Reviews 57(2):279-288 (2005).
Reiter E, Lefkowitz RJ. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling. Trends in Endocrinology and Metabolism 17(4):159-165, (2 0 0 6).
Beaulieu J-M et al. Akt/GSK3 signaling in the action of psychotropic drugs. Annu. Rev. Pharmacol, Toxicol. 2009; 49: 327-347.

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