Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-08-16
2011-08-16
Romeo, David (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S194000, C435S195000, C930S240000
Reexamination Certificate
active
07999075
ABSTRACT:
A method of screening a candidate compound for βArrestin mediated anti-G protein coupled receptor signaling activity is comprises: (a) contacting said candidate compound to a βArrestin signaling complex or a constituent thereof, under conditions in which a signaling complex is formed; and then (b) detecting the presence or absence of disruption of said signaling complex, disruption of said complex indicating said compound has βArrestin mediated anti-G protein coupled receptor signaling activity. Compositions and kits for carrying out the method are also described.
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Beaulieu Martin
Caron Marc G.
Gainetdinov Raul R.
Marion Sébastien
Sotnikova Tatiana D.
Duke University
Myers Bigel Sibley & Sajovec P.A.
Romeo David
LandOfFree
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