Methods for identifying compounds that modulate enzymatic...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C435S007100

Reexamination Certificate

active

10374499

ABSTRACT:
The present invention relates to methods for identifying compounds that modulate enzymatic activity by contacting covalently bonded PTP-extender complexes or modified covalently bonded PTP-extender complexes with ligand candidates.

REFERENCES:
patent: 5367058 (1994-11-01), Pitner et al.
patent: 6335155 (2002-01-01), Wells et al.
patent: 6811966 (2004-11-01), Wells et al.
patent: 6919178 (2005-07-01), Erlanson et al.
patent: 2002/0155505 (2002-10-01), Wells et al.
patent: WO 02/42773 (2002-05-01), None
patent: WO 03/014072 (2003-02-01), None
patent: WO 03/014308 (2003-02-01), None
patent: WO 03/046200 (2003-06-01), None
Yasothornsrkul, S.; Aaron, W.; Toneff, T.; Hook, V. Y. H. Evidence for the Proenkephalin Processing Enzyme Prohormone thiol Protease (PTP) as a Multicatalytic Cysteine Protease Complex. Biochemistry 1999, 38, 7421-7430.
Burke, T., et al., “Phosphoryltyrosyl Mimetics in the Design of Peptide-Based Signal Transduction Inhibitors”, Biopolymers (Peptide Science), vol. 60, 2001, pp. 32-44.
Erlanson, D., et al., “Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering”, Journal of American Chemical Society, Vo. 125, No. 19, 2003, 5602-5603.
Szczepankiewicz, B., et al., “Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy”, Journal of American Chemical Society, Vo. 125, No. 14, 2003, 4087-4096.
Daniel A. Erlanson, et al., “Site-directed Ligand Discovery”, PNAS, Aug. 15, 2000, vol. 97, No. 17, pp. 9367-9372.
Betley et al. Direct screening for Phosphatase Activity by Turnover-Based Capture of Protein Catalysts, Angew. Chem. Int. Ed. 2002, vol. 41, No. 5, pp. 775-777.
Erlanson et al. In-Situ Assembly of Enzyme Inhibitors Using Extended Tethering. Nature Biotechnology. Mar. 2003, vol. 21, pp. 308-314.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods for identifying compounds that modulate enzymatic... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying compounds that modulate enzymatic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying compounds that modulate enzymatic... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3796675

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.