Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-10-18
2005-10-18
Chan, Christina (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S375000
Reexamination Certificate
active
06955884
ABSTRACT:
The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. The invention is based on the discovery that CD38 ADP-ribosyl cyclase activity is required for chemotaxis. Furthermore, the invention relates to methods for identifying compounds that modulate the enzyme activity of theS. mansoniCD38 homologue and using those compounds in the treatment of pathologic disorders caused by helminth infection. This is based on the discovery that helminths such asS. mansoniexpress CD38 homologues.
REFERENCES:
patent: 5958723 (1999-09-01), Abramovitz et al.
Graeff R, Munshi C, Aarhus R, Johns M, Lee HC. A single residue at the active site of CD38 determines its NAD cyclizing and hydrolyzing activities. J. Biol. Chem. 2001;276:12169-12173.
Day TA, Haithcock J, Kimber M, Maule AG. Functional ryanodine receptor channels in flatworm muscle fibres. Parasitology 2000;120:417-422.
Munshi C, Aarhus R, Graeff R, Walseth TF, Levitt D, Lee HC. Identification of the enzymatic active site of CD38 by site-directed mutagenesis. J. Biol. Chem. 2000;275:21566-21571.
Guse AH. Cyclic ADP-ribose: a novel Ca2+mobilising second messenger. Cell. Signal 1999;11:309-316.
Guse AH, da Silva CP, Berg I, Skapenko AL, Weber K, Heyer P, Hohenegger M, Ashamu GA, Schulze-Koops H, Potter BV, Mayr GW. Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose. Nature 1999;398:70-73.
Lee HC. A unified mechanism of enzymatic synthesis of two calcium messengers: cyclic ADP-ribose and NAADP. Biol. Chem. 1999;380:785-793.
Lund FE, Muller-Steffner HM, Yu N, Stout CD, Schuber F, Howard MC. CD38 signaling in B lymphocytes is controlled by its ectodomain but occurs independently of enzymatically generated ADP-ribose or cyclic ADP-ribose. J. Immunol. 1999;162:2693-2702.
Munshi C, Thiel DJ, Mathews II, Aarhus R, Walseth TF, Lee HC. Characterization of the active site of ADP-bibosyl cyclase. J. Biol Chem 1999;274:30770-30777.
Berthelier V, Tixier JM, Muller-Steffner H, Schuber F, Deterre P. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem. J 1998;330:1383-1390.
Cockayne DA, Muchamuel T, Grimaldi JC, Muller-Steffner H, Randall TD, Lund FE, Murray R, Schuber F, Howard MC. Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood 1998;92:1324-1333.
Fernandez JE, Deaglio S, Donati D, Beusan IS, Corno F, Aranega A, Forni M, Falini B, Malavasi F. Analysis of the distribution of human CD38 and of its ligand CD31 in normal tissues. : J. Biol. Regul. Homeost. Agents 1998;12:81-91.
Silva CL, Cunha VM, Mendonca-Silva DL, Noel F. Evidence of ryanodine receptors in schistosoma mansoni. Biochem. Pharmacol. 1998;56:997-1003.
Graeff RM, Walseth TR, Lee HC. Radioimmunoassay for measuring endogenous levels of cyclic ADP-ribose in tissues. Methods Enzymol. 1997;280:230-241.
Higashida H, Yokoyama S, Hashii M, Taketo M, Higashida M, Takayasu T, Ohshima T, Takasawa S, Okamoto H, Noda M. Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes. J. Biol. Chem. 1997;272:31277-31277.
Vu CQ, Coyle DL, Jacobson MK. Natural occurrence of 2′-phospho-cyclic ADP ribose in mammalian tissues. Biochem. Biophys. Res. Commun. Jul. 30, 1997;236(3):723-726.
Vu CQ, Coyle DL, Tai HH, Jacobson EL, Jacobson MK. Intramolecular ADP-ribose transfer reactions and calcium signalling. Potential role of 2′-phospho-cyclic ADP-ribose in oxidative stress. Adv. Exp. Med. Biol. 1997;419:381-388.
Graeff RM, Walseth TF, Hill HK, Lee HC. Fluorescent analogs of cyclic ADP-ribose: synthesis, spectral characterization, and use. Biochemistry 1996;35:379-386.
Muller-Steffner HM, Augustin A, Schuber F. Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase. Mechanism of cyclization of pyridine nucleotides by bovine spleen NAD+ glycohydrolase. J. Biol. Chem. 1996;271:23967-23972.
Prasad GS, McRee DE, Stura EA, Levitt DG, Lee HC, Stout CD. Crystal structure of Aplysia ADP ribosyl cyclase, a homologue of the bifunctional ectozyme CD38. Nat. Struct. Biol. 1996;3:957-964.
Gadangi P, Longaker M, Naime D, Levin RI, Recht PA, Montesinos MC, Buckley MT, Carlin G, Cronstein BN. The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J. Immunol. 1996:156:1937-1941.
Aarhus R, Graeff RM, Dickey DM, Walseth TF, Lee HC. ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP. J. Biol. Chem. 1995;270:30327-30333.
Takashi K, Kukimoto I, Tokita K, Inageda K, Inoue S, Kontani K, Hoshino S, Nishina H, Kanaho Y, Katada T. Accumulation of cyclic ADP-ribose measured by a specific radioimmunoassay in differentiated human leukemic HL-60 cells with all-trans-retinoic acid. FEBS Lett. 1995;371:204-208.
Bronstein I, Fortin JJ, Voyta JC, Juo RR, Edwards B, Olesen CE, Lijam N, Kricka LJ. Chemiluminescent reporter gene assays: sensitive detection of the GUS and SEAP gene products. Biotechniques 1994;17:172-174, 176-177.
Day TA, Bennett JL, Pax RA. Serotonin and its requirement for maintenance of contractility in muscle fibres isolated fromSchistosoma mansoni. Parasitology 1994;108:425-432.
Day TA, Maule AG, Shaw C, Halton DW, Moore S, Bennett JL, Pax RA. Platyhelminth FMRFamide-related peptides (FaRPs) contractSchistosoma mansoni(Trematoda: Digenea) muscle fibres in vitro. Parasitology 1994;109:455-459.
Graeff RM, Walseth TF, Fryxell K, Branton WD, Lee HC. Enzymatic synthesis and characterization of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity. J. Biol. Chem. 1994;269:30260-30267.
Koguma T, Takasawa S, Tohgo A, Karasawa T, Furuya Y, Yonekura H, Okamoto H. Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans. Biochim. Biophys. Acta 1994;1223:160-162.
Murphy PM. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 1994;12:593-633.
Weis JH. ‘Race no more’: an alternative approach to cloning the 5′ end of transcripts. Nucleic Acids Res. 1994;22:3427-3428.
Day TA, Orr N, Bennett JL, Pax RA. Voltage-gated currents in muscle cells ofSchistosoma mansoni. Parasitology 1993;106:471-477.
Galione A, White A, Willmott N, Turner M, Potter BV, Watson SP. cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis. Nature 1993;365:456-459.
Harada N, Santos-Argumedo L, Chang R, Grimaldi JC, Lund FE, Brannan CI, Copeland NG, Jenkins NA, Heath AW, Parkhouse RM, Howeard M. Expression cloning of a cDNA encoding a novel murine B cell activation marker. Homology to human CD38. J. Immunol. 1993;151:3111-3118.
Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RM, Walseth TF, Lee HC. Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 1993;262:1056-1059.
Sorrentino V, Volpe P. Ryanodine receptors: how many, where and why? Trends Pharmacol. Sci. 1993;14:98-103.
Hakamato Y, Nakai J, Takeshima H, Imoto K. Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain. FEBS Lett 1992;312:229-235.
Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, Alt FW. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992;68:855-867.
Galione A, Lee HC, Busa WB. Ca(2+)-
Lund Frances E.
Partida-Sánchez Santiago
Randall Troy D.
Belyavskyi Michail A
Chan Christina
Trudeau Institute, Inc.
LandOfFree
Methods for identifying compounds that inhibit CD38 activity does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for identifying compounds that inhibit CD38 activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying compounds that inhibit CD38 activity will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3446854