Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
2006-06-27
2006-06-27
Spector, Lorraine (Department: 1649)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
C424S009100, C424S001450, C435S007200, C435S007210, C435S336000, C530S388240
Reexamination Certificate
active
07067113
ABSTRACT:
Screening methods for identifying compounds that bind to or activate (D1or D5dopamine receptors individually or in combination) or potentially regulate skeletal muscle mass or function in vivo. Also disclosed are screening methods for identifying compounds that prolong or augment the activation of D1or D5dopamine receptors or of D1or D5dopamine receptor signal transduction pathways and increase D1or D5dopamine receptor expression. Pharmaceutical compositions comprising D1or D5dopamine receptor agonists, antibodies to D1or D5dopamine receptors and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using D1or D5dopamine receptors as the target for intervention and methods for treatment of muscular dystrophies are described.
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Isfort Robert Joseph
Sheldon Russell James
Desai Naishadh N.
Spector Lorraine
Standley Steven
The Procter & Gamble & Company
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