Methods for identifying compounds for motion sickness,...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition

Reexamination Certificate

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C435S006120, C435S069100, C435S252300, C435S320100, C536S023100, C514S002600, C530S350000

Reexamination Certificate

active

10255536

ABSTRACT:
The present invention provides a method of identifying a compound that modulates a mammalian vestibular system. The method consists of administering a test compound to an invertebrate, and measuring a geotactic behavior of the invertebrate, where a compound that modulates the geotactic behavior of the invertebrate is characterized as a compound that modulates a mammalian vestibular system. The invention also provides a method of identifying a gene that modulates a mammalian vestibular system consisting of obtaining a first and a second strain of an invertebrate; subjecting the first and second invertebrate strains to conditions in which the first strain exhibits a geotactic behavior different than a geotactic behavior exhibited by the second strain; measuring gene expression levels in the first and second strains, and identifying one or more genes that are differentially expressed in the first strain relative to the second strain, whereby a mammalian gene having substantially the same nucleic acid sequence as the one or more differentially expressed genes modulates the mammalian vestibular system.

REFERENCES:
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