Methods for identifying chromosomal aneuploidy

Details Methods for identifying chromosomal aneuploidy Methods for identifying chromosomal aneuploidy

2005-12-27

2005-12-27

Goldberg, Jeanine A. (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C536S023100

Reexamination Certificate

active

06979541

ABSTRACT:
Methods are disclosed for identifying chromosomal aneuploidy using heterozygous SNPs in a melting curve analysis. In one aspect, a panel of SNPs may be used. The heterozygous nature of the SNPs may in some aspects, act as an internal control for the melting curve analysis, and alleviate the need for external controls or competitors. In another aspect, each of the SNP in the panel may have a heterozygocity index of greater than about 30%. While a number of aneuploidies may be identified using the disclosed methods, in one aspect, the chromosomal aneuploidy identified may be trisomy 21.

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