Methods for identifying biological macromolecule interactions wi

Details Methods for identifying biological macromolecule interactions wi Methods for identifying biological macromolecule interactions wi

1997-11-12

2000-04-25

Hannaher, Constantine

Radiant energy

Invisible radiant energy responsive electric signalling

Infrared responsive

25033912, G01N 2135

Patent

active

060547111

ABSTRACT:
Methods for determining whether a biological macromolecule binds to a compound are disclosed. The methods include: a) obtaining a Fourier-Transform Infrared spectrum of a solution which contains a biological macromolecule and obtaining a Fourier-Transform Infrared spectrum of a solution which includes a compound; b) obtaining a Fourier-Transform Infrared spectrum of a solution which contains the biological macromolecule and compound of step a); c) subtracting the Fourier-Transform Infrared spectrum of the biological macromolecule of step a) and the Fourier-Transform Infrared spectrum of the compound of step a) from the Fourier-Transform spectrum of step b) to determine a subtracted index; and d) determining that the compound of step a) binds to the biological macromolecule of step a) when the subtracted index of step c) is not equal to zero.

REFERENCES:
patent: 5519220 (1996-05-01), Truett
patent: 5539207 (1996-07-01), Wong
patent: 5578499 (1996-11-01), Ismail
Tomasz et al., "Isolation and Structure of a Covalent Cross-Link Adduct Between Mitomycin C and DNA", Science 235: 1204-1208, Mar. 1987.
Barth et al., "Infrared Spectroscopic Signals Arising from Ligand Binding and Conformational Changes in the Catalytic Cycle of Sarcoplasmic Reticulum Calcium ATPase", Biochem. Biophys. Acta 1057:115-123, Mar. 1991.

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