Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-02-19
2010-02-09
Chen, Shin-Lin (Department: 1632)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S040500, C435S004000, C435S325000, C530S350000, C514S001000
Reexamination Certificate
active
07659082
ABSTRACT:
The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.
REFERENCES:
patent: 5356777 (1994-10-01), Hoffman et al.
patent: 6110672 (2000-08-01), Mandel et al.
patent: 7195879 (2007-03-01), Dubin et al.
patent: 0 789 575 (2008-09-01), None
patent: WO 96/14077 (1996-05-01), None
patent: WO 03/087769 (2003-10-01), None
Rudinger, 1976, Peptide Hormones, Parsons, University Park Press, Baltimore, p. 1-7.
Kaye et al., 1990, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 6922-6926.
Skolnick et al., 2000, Trends in Biotech, vol. 18, p. 34-39.
Klugbauer et al., GenBank No. NP—002968 (Oct. 31, 2000).
Sangameswaran et al., J. Biol. Chem. vol. 272, pp. 14805-14809 (1997).
Cox et al., “An SCN9A Channelopathy Causes Congenital Inability to Experience Pain,” Nature, vol. 44, pp. 894-898 (2006).
Cronin et al., “Binding of the Anticonvulsant Drug Lamotrigine . . . ” J. Biol. Chem., vol. 278, pp. 10675-10682 (2003).
Krafte et al., “Sodium channels and nociception: recent concepts and therapeutic opportunities,” Curr. Opin. Pharm., vol. 8, pp. 50-56 (2008).
McNulty et al., “State-dependent Mibefradil Block of Na+ Channels,” Mol. Pharm., vol. 66, pp. 1652-1661 (2004).
Goldberg Yigal P.
MacDonald Marcia L.
Samuels Mark E.
Sherrington Robin
Chen Shin-Lin
Grant Alan J.
Olstein Elliot M.
Xenon Pharmaceuticals Inc.
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