Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Reexamination Certificate
2005-10-18
2005-10-18
Marschel, Aroin H. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
C702S019000, C702S022000
Reexamination Certificate
active
06957150
ABSTRACT:
This invention is directed to Acyl Carrier Protein Synthase (ACPS) crystals and crystals of Acyl Carrier Protein Synthase-Coenzyme A (ACPS-CoA) complex, and to the use of these crystals to determine the three dimensional structure of ACPS. This invention is further directed to the use of rational drug design methods to identify agents that may interact with active sites of ACPS and ACPS-CoA complex, and to the testing of these agents to identify agents that may inhibit ACPS and/or ACPS-CoA complex activity.
REFERENCES:
patent: 5096676 (1992-03-01), McPherson et al.
patent: 5221410 (1993-06-01), Kushner et al.
Jan Drenth, Principles of Protein X-ray Crystallography, 1995, Springer-Verlag, p. 16).
Rosowsky et al., 1999, J. Med. Chem., 42, 4853-4860.
Ahern, Holly, May 13, 196, The Scientist 10[10], May 13, 1996, pp. 1-4.
Tripos Inc., Sybyl Product Sheet.
Jan Drenth, Principles of Protein X-ray Crystallography, 1994, Springer-Verlag, pp. 93-95.
News Focus, Science, Nov. 1, 2002, vol. 298, pp. 948-950.
Knegtel et al., Molecular docking to ensembles of protein structures. J. Mol. Biol., 266:424-40, Feb. 2, 1997.
Lambalot et al., A new enzyme superfamily—the phosphopantetheinyl transferases. Chemistry & Biology, 3(11):923-36, Nov. 1996.
Makino and Kuntz, Automated flexible ligand docking method and its application for database search. Journal of Computational Chemistry, 18(14):1812-25, Nov. 15, 1997.
Parris et al., Crystal structures of substrate binding toBacillus subtilisholo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure, 8:883-95, Jul. 27, 2000.
Qui et al., Crystal structure of β-ketoacyl-acyl carrier protein synthase III. The Journal of Biological Chemistry, 274(51):36,465-471, Dec. 17, 1999.
Reuter et al., Crystal structure of the surfactin synthetase -activating enzyme Sfp: a prototype of the 4′-phosphopantetheinyl transferase superfamily. EMBO J., 18(23):6823-31, 1999.
Lin Laura Long
Parris Kevin Delos
Somers William Stuart
Stahl Mark Lloyd
Tam Amy Szepui
Fish & Richardson P.C.
Ly Cheyne D
Marschel Aroin H.
Millennium Pharmaceuticals Inc.
Wyeth
LandOfFree
Methods for identifying an agent that interacts with an... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for identifying an agent that interacts with an..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying an agent that interacts with an... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3483653