Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-11-20
2007-11-20
Saoud, Christine J. (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C435S252300, C435S320100, C435S375000, C435S325000, C530S350000, C536S023100
Reexamination Certificate
active
09346794
ABSTRACT:
Sequences and partial sequences for three types of mammalian (human and rat) sequences identified) T-type calcium channel subunits which we have labeled as the α1G, α1Hand α1Isubunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying compounds capable of acting as agonists or antagonists to the calcium channels.
REFERENCES:
patent: 5386025 (1995-01-01), Jay et al.
patent: 5401629 (1995-03-01), Harpold et al.
patent: 5429921 (1995-07-01), Harpold et al.
patent: 5688938 (1997-11-01), Brown et al.
patent: 5804436 (1998-09-01), Okun et al.
patent: 5837479 (1998-11-01), Young et al.
patent: 6309858 (2001-10-01), Dietrich et al.
patent: 6358706 (2002-03-01), Dubin et al.
patent: 6528630 (2003-03-01), Williams et al.
patent: 2003/0125269 (2003-07-01), Li
patent: WO 95/04144 (1995-02-01), None
patent: WO 96/39512 (1996-12-01), None
patent: WO 98/38301 (1998-09-01), None
patent: WO 99/28342 (1999-06-01), None
patent: WO 99/29847 (1999-06-01), None
patent: WO 00/7044 (2000-11-01), None
patent: WO 01/19845 (2001-03-01), None
Williams et al, Structure and Functional Expression of Alpha1, Alpha2, and Beta Subunits of a Novel Human Neuronal Calcium Channel Subtype, Jan. 1992, Neuron, vol. 8, pp. 71-64.
Sylvia et al, Low-voltage-activated T-type Ca2+ Channels, Feb. 1997, TIPS, vol. 18, pp. 37-42.
Bork et al. Predicting Functions From Protein Sequences-Where Are The Bottlenecks, 1998, Nature Genetics, vol. 18, pp. 313-318.
Karp et al., Editorial, Bioinformatics, 1998, vol. 14, No. 9, pp. 753-754.
Bork et al., Sequences and Topolgy Deriving biological Knowlwdge from genomic sequences, 1998, current Opinion in structural Biology, vol. 8, pp. 331-332.
Perez-Reyes, E., et al, “Molecular characterization of a neuronal low-voltage-activated T-type calcium channel”, Nature 391:896-900, Feb. 26, 1998.
Cribbs, L.L., et al, “Cloning and Characterization of alpha-1H From Human Heart, a Member of the T-Type Ca2+ Channel Gene Family”, Circ. Res. 83:103-109, Jul. 13, 1998.
Williams, M.E., et al, “Structure and Functional Characterization of a Novel Human Low-Voltage Activated Calcium Channel”, J. Neurochem. 72(2):791-799, 1999.
Lee, J-H., et al, “Cloning and Expression of a Novel Member of the Low Voltage-Activated T-Type Calcium Channel Family”, J. Neurosci, 19(6):1912-1921, Mar. 15, 1999.
Trofatter, J.A., et al, “An Expression-independent Catalog of Genes from Human Chromosome 22”, Genome Res. 5(3):214-224, Oct. 1995, United States, XP002069420.
Trofatter, J.A., et al., “An Expression-independent Catalog of Genes from Human Chromosome 22”, Genome Research 5(3):214-224, Oct. 1995.
Stratagene catalog (1991) p. 66.
Brizzard and Chubet, Current Protocols in Neuroscience (1997) 5.8.1-5.8.10.
Pubmed search results for “t-type calcium channel Parkinson's” and “t-type calcium channel schizophrenia”, accessed Sep. 27, 2005.
Partial European Search Report for EP 06 11 5615, mailed on Feb. 27, 2007, 4 pages.
Mittman et al., Neuroscience Letters (1999) 274(3):143-146.
Baillie David L.
Snutch Terry P.
Basi Nirmal S.
Morrison & Foerster / LLP
Neuromed Pharmaceuticals Ltd.
Saoud Christine J.
LandOfFree
Methods for identifying agonists and antagonists of human... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for identifying agonists and antagonists of human..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying agonists and antagonists of human... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3852479