Methods for identifying agents which block the interaction of fy

Details Methods for identifying agents which block the interaction of fy Methods for identifying agents which block the interaction of fy

1996-01-31

1998-07-07

Grimes, Eric

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435 5, 435 78, C12Q 148, C12Q 170

Patent

active

057767165

ABSTRACT:
The present invention discloses that the fyn protein binds to the PKC-theta protein. Based on this observation, the present invention provides methods of identifying agents which can be used to modulate immune system activity by blocking fyn/PKC-theta binding and therapeutic methods using such agents.

REFERENCES:
patent: 5283173 (1994-02-01), Fields et al.
patent: 5352660 (1994-10-01), Pawson
patent: 5580979 (1996-12-01), Bachovchin
Penninger et al., Immunol. Rev. 135: 183-214, 1993.
Rickles et al., EMBO J. 13:5598-5604, 1994.
Baier et al., J.Biol. Chem. 268:4997-5004, 1993.
Dalyrmple, M.A. et al., "The Product of the PRP4 Gene of S. cerevisiae Shows Homology to .beta. Subunits of G Proteins," Cell 58:811-812 (1989).
Dynlacht, B.D. et al., "The dTAF. . 80 subunit of Drosphila TFIID contains .beta.-transducin repeats," Nature 363: 176-179 (1993).
Fong, H.K.W. et al., "Repetitive segmental structure of the transducin .beta. subunit: Homology with the CDC4 gene and identificationof related mRNAs," Proc. Natl. Acad. Sci. USA 83: 2162-2166 (1986).
Guillemot, F. et al., "Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex," Proc. Natl. Acad. Sci. USA 86: 4594-459 (1989).
Keleher, C.A. et al., "Ssn6-Tup 1 Is a General Repressor of Transcription in Yeast," Cell 68: 709-719 (1992).
Mochly-Rosen, D. et al., "Identification of intracellular receptor proteins for activated protein kinase C," Proc. Natl. Acad. Sci. USA 88: 3997-4000 (1991).
Mochly-Rosen, D. et al., "Intracellular Receptors for Activated Protein Kinase C," J. Biol. Chem 266(23): 14866-14868 (1991).
Peitsch, M.C. et al., "Sequence similarity of phospholipase A2 activating protein and the G protein .beta.-subunits: a new concept of effector protein activation in signal transduction?," TIBS 18(8): 292-293 (1993).
Ron, D. et al. "An Autoregulatory Region in Protein Kinase C: The Pseudoanchoring Site" Proc. Natl. Acad. Sci. USA 92:492-496 (1995).
Ron, D. et al. "Agonists and Antagonists of Protein Kinase C Function, Derived from its Binding Proteins" J. Biol. Chem. 269:21395-21398 (1994).
Ron, D. et al. "Cloning of an Intracellular Receptor for Protein Kinase C: A Homolog of the Beta Subunit of G Proteins" Proc. Natl. Acad. Sci. USA 91:839-843 (1994).
Ruggieri, R., et al. "MSI1, a Negative Regulator of the RAS-cAMP Pathway in Saccharomyces Cerevisiae" Proc. Natl. Acad. Sci. USA 86:8778-8782 (1989).
Smith, B.L. and Mochly-Rosen, D., "Inhibition of Protein Kinase C Function by Injection of Intracellular Receptors for the Enzyme," Biochem. Biophys. Res. Comm. 188(3): 1235-1240 (1992).
Takagaki, Y. and Manley, J.L., "A Human Polyadenylation Factor Is a G Protein .beta.-subunit Homologue," J. Biol. Chem 267(33): 23471-23474 (1992).
Tamaki, M. et al. "Rat Lipocortin I cDNA" Nucleic Acids Res. 15:7637 (1987).
van der Voorn, L. and Ploegh, H.L., "The WD-40 repeat," FEBS Lett. 307(2): 131-134 (1992).
Wallner, B., et al. "Cloning and Expression of Human Lipocortin, a Phospholipase A2 Inhibitor with Potential Anti-Inflammatory Activity" Nature 320:77-81 (1986).
Weinstat-Saslow et al., "A Transducin-like Gene Maps to the Autosomal Dominant Polycystic Kidney Disease Gene Region" Genomics 18:709-711 (1993).
Williams, F.E. and Trumbly, R.J., "Characterization of TUP1, a Mediator of Glucose Repression in Saccharomyces cerevisiae," Mol. Cell. Biol. 10(12): 6500-6511 (1990).
Williams, F.E. et al., "The CYC8 and TUP1 Proteins Involved in Glucose Repression in Saccharomyces cerevisiae Are Associated in a Protein Complex," Mol. Cell. Biol. 11(6): 3307-3316 (1991).
Derwent Publications Ltd., AN 94-026226 (1994).

Affiliated with

Also associated with

Rating

Methods for identifying agents which block the interaction of fy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for identifying agents which block the interaction of fy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for identifying agents which block the interaction of fy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1204297