Methods for identifying agents that interact with MAP kinase...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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Reexamination Certificate

active

10294027

ABSTRACT:
This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.

REFERENCES:
patent: 6820011 (2004-11-01), Chen et al.
patent: WO 03/048340 (2003-06-01), None
patent: WO 03/076333 (2003-09-01), None
Meng, Wuyi, et al., entitled “Structure of Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinase 2 Suggests a Bifunctional Switch That Couples Kinase Activation with Nuclear Export,” The Journal of Biological Chemistry, vol. 277, No. 40 Issue of Oct. 4, pp. 37401-37405, 2002. Published JBC papers in press, Aug. 8, 2002.
Ben-Levy, R., Hooper, S., Wilson, R., Paterson, H.F., Marshall, C.J. (1998) Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2.Curr. Biol.8, 1049-1057.
Ben-Levy, R., Leighton, I., Doza, Y., Attwood, P., Morrice, N., Marshall, C., Cohen, P. (1995) Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.EMBO J.14, 5920-5930.
Clifton, A.D., Young, P.R., Cohen, P. (1996) A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.FEBS Letters392, 209-214.
Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R., Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.FEBS Letters364, 229-233.
Engel, K., Kotlyarov, A., Gaestel, M. (1998) Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation.EMBO J.17, 3363-3371.
Engel, K., Plath, K., Gaestel, M. (1993) The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.FEBS Letters336, 143-147.
Engel, K., Schultz, H., Martin, F., Kotlyarov, A., Plath, K., Hahn, M., Heinemann, U., Gaestel, M. (1995) Constitutive Activation of Mitogen-activated Protein Kinase-activated Protein Kinase 2 by Mutation of Phosphorylation Sites and an A-helix Motif.J. Biol. Chem.270, 27213-27221.
Goldberg, J., Nairn, A.C., Kuriyan, J. (1996) Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I.Cell84, 875-87.
Hedges, J.C., Dechert, M.A., Yamboliev, I.A., Martin, J.L., Hickey, E., Weber, L.A., Gerthoffer, W.T. (1999) A Role for p38MAPK/HSP27 Pathway in Smooth Muscle Cell Migration.J. Biol. Chem.274, 24211-24219.
Huse, M., Kuriyan, J. (2002) The Conformational Plasticity of Protein Kinase.Cell109, 275-282.
Johnson, L.N., Noble, M.E.M., Owen, D.J. (1996) Active and Inactive Protein Kinases: Structural Basis for Regulation.Cell85, 149-158.
Komatsu, S., Murai, N., Totsukawa, G., Abe, M., Akasaka, K., Shimada, H., Hosoya, H. (1997) Identification of MAPKAPK homolog (MAPKAPK-4) as a myosin II regulatory light-chain kinase in sea urchin egg extracts. Arch.Biochem. Biophys.343, 55-62.
Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H.-D., Gaestel, M. (1999) MAPKAP kinase 2 is essential for LPS-induced TNF- biosynthesis.Nat. Cell. Biol.1, 94-97.
Kotlyarov, A., Yannoni, Y., Fritz, S., Laass, K., Telliez, J.-B., Pitman, D., Lin, L.-L., Gaestel, M. (2002) Distinct Cellular Function of MK2.Mol. Cell Biol.22, 4827-4835.
Lavoie, J., Hickey, E., Weber, L., Landry, J. (1993) Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27.J. Biol. Chem.268, 24210-24214.
Lee, J.C., Laydon, J.T., McDonnel, P.C., Gallagher, T.F., Kumar, S., Green, D., McNulty, D., Blumenthal, M.J., Heys, J.R., Landvatter, S.W., et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.Nature372, 739-746.
Mayans, O., van der Ven, P.F.M., Wilm, M., Mues, A., Young, P., Furst, D.O., Wilmanns, M., Gautel, M. (1998) Structural basis for activation of the titin kinase domain during myofibrillogenesis.Nature395, 863-869.
McLaughlin, M.M., Kumar, S., McDonnell, P.C., Van Horn, S., Lee, J.C., Livi, G.P., Young, P.R. (1996) Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase.J. Biol. Chem.271, 8488-8492.
Neininger, A., Kontoyiannis, D., Kotlyarov, A., Winzen, R., Eckert, R., Volk, H.-D., Holtmann, H., Kollias, G., Gaestel, M. (2002) MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional Levels.J. Biol. Chem.277, 3065-3068.
Ni, H., Wang, X.S., Diener, K., Yao, Z. (1998) MAPKAPK5, a Novel Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase, Is a Substrate of the Extracellular-Regulated Kinase (ERK) and p38 Kinase.Biochem. Biophys. Res. Commun.243, 492-496.
Prade, L., Engh, R.A., Girod, A., Kinzel, V., Huber, R., Bossemeyer, D. (1997) Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.Structure5, 1627-37.
Stokoe, D., Campbell, D., Nakielny, S., Hidaka, H., Leevers, S., Marshall, C., Cohen, P. (1992) MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.EMBO J.11, 3985-3994.
Stokoe, D., Caudwell, B., Cohen, P.T., Cohen, P. (1993) The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.Biochem. J296, 843-849.
Stokoe, D., Engel, K., Campbell, D.G., Cohen, P., Gaestel, M. (1992) Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.FEBS Letters313, 307-313.
Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., Comb, M. (1996) FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.EMBO J.15, 4629-4642.
Tanoue, T., Adachi, M. Moriguchi, T., Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators.Nat. Cell. Biol.2, 110-116.
Veron, M., Radzio-Andzelm, E., Tsigelny, I., Eyck, L., Taylor, S. (1993) A Conserved Helix Motif Complements the Protein Kinase Core.Proc. Natl. Acad. Sci.90, 10618-10622.
Zheng, J.H., Trafny, E.A., Knighton, D.R., Xuong, N.H., Taylor, S.S., Teneyck, L.F., Sowadski, J.M. (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with magnesium-ATP and peptide inhibitor.Biochemistry32, 2154-61.
Zu, Y.-L., Wu, F., Gilchrist, A., Ai, Y., Labadia, M.E., Huang, C.-K. (1994) The Primary Structure of a Human MAP Kinase Activated Protein Kinase 2.Biochem. Biophys. Res. Commun.200, 1118-1124.

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