Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-04-12
2005-04-12
Padmanabhan, Sreeni (Department: 1617)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C424S009100, C424S009200, C514S002600
Reexamination Certificate
active
06878514
ABSTRACT:
The invention described herein encompasses methods of preventing or treating disorders caused by oxidative damage by an aging-specific isoform of NADH oxidase (AR-NOX). The invention encompasses methods of assaying, screening, and identifying agents that inhibit AR-NOX, as well as methods using ubiquinone to inhibit the ability of AR-NOX to generate reactive oxygen species. These agents may be formulated into pharmaceutical compositions in the prevention and treatment of disorders caused by oxidative damage.
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Lenaz
Morre D. James
Morre Dorothy M.
Jones Day
Padmanabhan Sreeni
Purdue Research Foundation
Wells Lauren Q.
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