Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-02-28
1996-07-16
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 536 243, 536 2431, 935 77, 935 78, C07H 2164, C12P 1934, C12Q 168
Patent
active
055366368
ABSTRACT:
The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i.e., increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.
REFERENCES:
Suijkerbuijk et al. Am. J. Hum. Genet. 48:269-273, 1991.
Perre et al. Hum. Genet. 87:231-233, 1991.
Koch, C. Anne et al., "SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins", Science 252:668-674 (May 1991).
Tonks, N. K., "Protein Phosphateses: Key Players in the Regulation of Cell function", Current Opinion in Cell Biology 2:1114-1124 (1990).
Hunter, Tony, "Protein-Tyrosine Phosphatases: The Other Side of the Coin", Cell 58:1013-1016 (l989).
Gewirtz, Alan M. and Hoffman, Ronald, "Human Megakaryocyte Production: Cell Biology and Clinical Considerations", Hematology/Oncology Clinics of North America 4(1):43-64 (Feb. 1990).
Shen, Shi-Hsiang et al., "A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases", Nature 352:736-739, (Aug. 1991), including correction page, Nature 353:868 (Oct. 1991).
Yi, Taolin et al., "Protein Tyrosine Phosphatase Containing SH2 domains: Characterization, Preferential Expression in Hematopoietic Cells, and Localization to Human Chromosome 12p12-p13", Molecular and Cellular Biology 12(2):836-848 (Feb. 1992).
Plutzky, Jorge et al., "Isolation of a src homology 2-containing tyrosine phosphatase", Proc. Natl. Acad. Sci. USA 89:1123-1127 (Feb. 1992).
Lathe, R., "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data Theoretical and Practical Considerations", J. Mol. Biol. 183:1-12 (1985).
Chernoff, Jonathan et al., "Cloning of a cDNA for a major human protein-tyrosine-phosphatase", Proc. Natl. Acad. Sci. USA 87:2735-2739 (Apr. 1990).
Charbonneau, Harry et al., "Human placenta protein-tyrosine-phosphatase: Amino acid sequence and relationship to a family of receptor-like proteins", Proc. Natl. Acad. Sci. USA 86:5252-5256 (Jul. 1989).
Fischer, E. H. et al., "Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes", Science 253:401-406 (Jul. 1991).
Perkins, Lizabeth A. et al., "corkscrew Encodes a Putative Protein Tyrosine Phosphatase That Functions to Transducer the Terminal Signal from the Receptor Tyrosine Kinase torso", Cell 70:225-236 (Jul. 1992).
Matthews, R. J., et al., "Characterization of Hematopoietic Intracellular Protein Tyrosine Phosphatases: Description of a Phosphatase Containing an SH2 Domain and Another Enriched in Proline-, Glutamic Acid-, Serine-, and Threonine-Rich Sequences", Mol. and Cell. Biol. 12(5):2396-2405 (May 1992).
Feng, G-S., et al., "SH2-Containing Phosphotyrosine phosphatase as a Target of Protein-Tyrosine Kinases", Science 259:1607-1611 (Mar. 1993).
Vogel, W., et al., "Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation", Science 259:1611-1614 (Mar. 1993).
Ahmad, S., et al., "A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains", Proc. Natl. Acad. Sci. USA 90:2197-2201 (Mar. 1993).
Songyang, Z., et al., "SH2 Domains Recognize Specific Phosphopeptide Sequences", Cell 72:767-778 (Mar. 1993).
Freeman, Robert M., et al., "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: A putative homolog of Drosophila corkscrew", Proc. Natl. Acad. Sci. USA 89:11239-11243 (1992).
Freeman, Jr. Robert M.
Neel Benjamin G.
Plutzky Jorge
Rosenberg Robert D.
Beth Israel Hospital
Jones W. Gary
Massachusetts Institute of Technology
Tran Paul B.
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