Methods for identification of novel protein drug targets and...

Details Methods for identification of novel protein drug targets and... Methods for identification of novel protein drug targets and...

2011-08-16

2011-08-16

Skowronek, Karlheinz R (Department: 1631)

Data processing: structural design, modeling, simulation, and em

Simulating nonelectrical device or system

Biological or biochemical

Reexamination Certificate

active

08000949

ABSTRACT:
The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational skeletons for integrating various types of high-throughput data. The present invention provides the first metabolic reconstruction study of a eukaryotic organism based solely on expressed sequence tag (EST) data. System Reconstruction also provides a method for the identification of novel therapeutic targets and biomarkers using network analysis. The initial seed networks are built from the lists of novel targets for diseases with the high-throughput experimental data being superimposed on the seed networks to identify specific targets.

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