Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-08-16
2010-10-05
Woolwine, Samuel (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100, C536S024310, C536S024330
Reexamination Certificate
active
07807370
ABSTRACT:
Animals with mutations in SILV present with the merle coat color pattern phenotype. Methods for the identification of animals that harbor a mutation in the SILV gene are described. Mutations in the SILV gene can be identified from any biological sample such as a cell or tissue that contains genomic DNA. A microsatellite marker identified using linkage disequilibrium mapping that segregates with merle is also described.
REFERENCES:
patent: 4582788 (1986-04-01), Erlich
patent: 4656127 (1987-04-01), Mundy et al.
patent: 4683194 (1987-07-01), Saiki et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4988617 (1991-01-01), Landegren et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5324633 (1994-06-01), Fodor et al.
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5552270 (1996-09-01), Khrapko et al.
patent: 2003/0211486 (2003-11-01), Frudakis
patent: 2006/0183127 (2006-08-01), Oulmouden et al.
patent: 0 050 424 (1982-04-01), None
patent: 0 084 796 (1983-08-01), None
patent: 0 201 184 (1986-11-01), None
patent: 0 237 362 (1987-09-01), None
patent: 0 258 017 (1988-03-01), None
patent: 2 650 840 (1991-02-01), None
patent: 2 857 979 (2005-01-01), None
patent: WO 89/10977 (1989-11-01), None
patent: WO 90/15070 (1990-12-01), None
patent: WO 91/02087 (1991-02-01), None
patent: WO 91/17239 (1991-11-01), None
patent: WO 92/10588 (1992-06-01), None
patent: WO 92/15712 (1992-09-01), None
patent: WO 92/16655 (1992-10-01), None
patent: WO 93/17126 (1993-09-01), None
patent: WO 94/11530 (1994-05-01), None
GenBank GI:189789 [online] Apr. 28, 1996 [retrieved on Nov. 6, 2009] retrieved from http://www.ncbi.nlm.nih.gov
uccore/189789.
GenBank GI:1125061 [online] Aug. 7, 2000 [retrieved on Nov. 6, 2009] retrieved from http://www.ncbi.nlm.nih.gov
uccore/1125061.
GenBank GI:67966276 [online] Jun. 18, 2005 [retrieved on Nov. 6, 2009] retrieved from http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?67966276:OLD04:3557506.
Abdelhak, et al., “Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1”,Hum. Mol. Genet., 6(13):2247-55 (1997).
Bailin, et al. “Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus”, J. Invest. Dermatol., 106(1):24-7 (1996).
Baldwin, “An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome”,Nature, 355(6361):637-638 (1992).
Baxter and Pavan, “Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development”,Gene Expr. Patterns, 3(6):703-7 (2003).
Choi, et al., “Three cases of Waardenburg syndrome type 2 in a Korean family”,Korean J. Ophthalmol., 18(2):185-189 (2004).
Clark, et al., “Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog”,Genomics, 84(3):550-4 (2004).
Clark, et al., “Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog”,Proc. Natl. Acad. Sci., USA, 103(5):1376-81 (2006).
Cordaux and Batzer, “Teaching an old dog new tricks: SINEs of canine genomic diversity”,Proc. Natl. Acad. Sci. USA, 103(5):1157-8 (2006).
Dausch, et al., “Ophthalmological findings in Merle dachshunds”,Dtsch. Tierarztl. Wochenschr., 84(12):468-75 (1977) (w/ English Abstract).
Du, et al., “MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma”,Am. J. Pathol., 163(1):333-43 (2003).
EMBL Nucleotide Sequence Database, “Accession No. C01052”, Jul. 17, 1996.
EMBL Nucleotide Sequence Database, “Accession No. CE177786”, Sep. 29, 2003.
Fletcher, et al., “Evaluation of a short interspersed nucleotide element in the 3' untranslated region of the defective dystrophin gene of dogs with muscular dystrophy”,Am. J. Vet. Res., 62(12):1964-8 (2001).
Gelatt & McGill, “Clinical characteristics of microphthalmia with colobomas of the Australian Shepherd Dog”,J. Am. Vet. Med. Assoc., 162(5):393-396 (1973).
Guyon, et al., “A 1-Mb resolution radiation hybrid map of the canine genome”,Proc. Natl. Acad. Sci. USA, 100(9):5296-301 (2003).
Hedan, et al., “Coat colour in dogs: identification of the merle locus in the Australian shepherd breed”,BMC Vet. Res., 27;2:9 (2006).
Jeoung, et al. “A SINE element in the canine D2 dopamine receptor gene and its chromosomal location”,Anim. Genet., 31(5):334-5 (2000).
Kerje, et al., “The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene”,Genetics, 168(3):1507-18 (2004).
Kirkness, et al., “The dog genome: survey sequencing and comparative analysis”,Science, 301(5641):1898-903 (2003).
Klinchmann, et al. “Light microscopy studies of the cornea of Merle dachshunds”,Dtsch. Tierarztl. Wochenschr., 94(6):338-41 (1987) (w/ English Abstract).
Klinckmann and Wegner, “Tonometry in Merle dogs”,Dtsch. Tierarztl. Wochenschr., 94(6):337-8 (1987) (w/ English Abstract).
Kushimoto, et al., “A model for melanosome biogenesis based on the purification and analysis of early melanosomes”,Proc. Natl. Acad. Sci. USA, 98(19):10698-703 (2001).
Kwon, et al., “A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12”,Proc. Natl. Acad Sci. USA, 88(20):9228-9232 (1991).
Kwon, et al., “Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17”,Nucleic Acids Research, 23(1):154-158 (1995).
Lin, et al., “The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene”,Cell, 98(3):365-76 (1999).
McCallion and Chakravarti, “EDNRB/EDN3 and Hirschsprung disease type II”,Pigment Cell Res., 14(3):161-169 (2001).
Minnick, et al., “A highly repetitive DNA sequence possibly unique to canids”,Gene, 110(2), 235-238 (1992).
Mitchell, “Dominant dilution and other color factors in collie dogs”,J. Hered., 26:425-430 (1935).
Nayak and Isaacson, “Worldwide distribution of Waardenburg syndrome”,Ann. Otol. Rhinol. Laryngol., 112(9 Pt 1):817-20 (2003).
Neff, et al., “Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage”,Proc. Natl. Acad. Sci. USA, 101:11725-11730 (2004).
Nichols, et al., “A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats”,J. Invest. Dermatol., 121(4):821-30 (2003).
O'Sullivan & Robinson, “Harlequin colour in the Great Dane dog”,Genetica, 78(3):215-8 (1988-1989).
Pele, et al., “Harlequin colour in the Great Dane dog”,Hum. Mol. Genet., 14, 1417-1427 (2005).
Philipp, et al., “Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs”,BMC Genet., 6:34 (2005).
Pingault, et al., “SOX10 mutations in patients with Waardenburg-Hirschsprung disease”,Nat. Genet., 18(2):171-173 (1998).
Probe, et al., “A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides”,Science, 238:336-341 (1987).
Puffenberger, et al., “A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease”,Cell, 79(7):1257-1266 (1994).
Ray, et al., “A highly polymorphic RFLP marker in the canine transducin alpha-1 subunit gene”,Animal Genetics, 27:372-373 (1996).
Ray, et al., “Molecular diagnostic test for ascertainment of genotype at the rod cone dysplasia (RCD1) locus in Irish Setters”,Current Eye Research, 14:243-247 (1995)
Clark Leigh Anne
Murphy Keith E.
Rees Christine
Wahl Jacquelyn
Merlogen, LLC
Pabst Patent Group LLP
Woolwine Samuel
LandOfFree
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