Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-05-02
2006-05-02
Parkin, J. S. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C424S188100, C424S208100, C424S085100
Reexamination Certificate
active
07037645
ABSTRACT:
The present invention relates to a bioactive molecule, herein referred to as the CD8+suppressor molecule, that is produced by the CD8+subset of human T-lymphocytes and suppresses type-1 human immunodeficiency virus (HIV-1) replication through inhibition of viral transcription. The invention relates to isolation of CD8+cell lines and cell clones that produce that antiviral activity and to the development of assay systems for detection of the antiviral activity. The cell lines, cell clones and assay systems, described herein, may be utilized, e.g., to purify, characterize and clone the CD8+suppressor molecule. The CD8+suppressor molecule may have therapeutic applications for treatment of diseases associated with HIV-1 infection.
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Hsu MC, Schutt AD, Holly M, Slice LW, Sherman MI,
Bolognesi Dani P.
Greenberg Michael L
Lacey Simon F
Tomaras Georgia D
Weinhold Kent J.
Duke University
Jones Day
Parkin J. S.
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