Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-12-11
2007-12-11
Shibuya, Mark L. (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C530S350000
Reexamination Certificate
active
11152366
ABSTRACT:
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.
REFERENCES:
patent: 6538173 (2003-03-01), Heber-Katz
patent: 2002/0151681 (2002-10-01), Rosen et al.
patent: 2005/0112118 (2005-05-01), Cimbora et al.
patent: 02/056888 (2002-07-01), None
patent: 2004/037814 (2004-05-01), None
patent: WO 2005/012875 (2005-02-01), None
U.S. Appl. No. 11/251,465, filed Sep. 2005, Brys et al.
Ni et al., MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase, 1998, Biochemical and Biophysical Research Communications, vol. 243, pp. 492-496.
Crowe et al., 1999, Regualtion of tumor cell invasion by extracellular matrix, Histol. Histopathol., 14: 665-671.
Ravanti et al., 2000, Matrix metalloproteinases in wound repair (Review), International Journal of Molecular Medicine, 6: 391-407.
Widmann et al., 1999, Mitogen-activated proteins kinase: Conservation of a three-kinase module form yeast to human, Physiological Reviews, 79(1): 143-180.
Shi et al., “Elimination of Protein Kinase MK5/PRAK Activity by Targeted Homologous Recombination,” Molecular and Cellular Biology, Nov. 2003, pp. 7732-7741.
Seternes et al., “Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress,” Molecular and Cellular Biology, Oct. 2002, pp. 6931-6945.
New et al., “PRAK, a novel protein kinase regulated by the p38 MAP kinase,” EMBO Journal, vol. 17, No. 12, pp. 3372-3384 (1998).
Bain et al., “The specificities of protein kinase inhibitors: an update,” Biochem, J. 371, pp. 199-204.
Setemes et al., “Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway,” EMBO Journal 23, pp. 4780-4791 (2004).
Brys Reginald
Tomme Peter Herwig Maria
Vandeghinste Nick
Galapagos N.V.
Shibuya Mark L.
Steele Amber D
Synnestvedt & Lechner LLP
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