Methods for identification, and compounds useful for the...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C530S350000, C506S009000

Reexamination Certificate

active

07919259

ABSTRACT:
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or anti-inflammatory pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving extra-cellular matrix degradation in a subject.

REFERENCES:
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patent: WO 99/38980 (1999-08-01), None
patent: 0014250 (2000-03-01), None
patent: 02079405 (2002-10-01), None
Lin et al., 1994, Effect of manganese on tyrosylprotein sulfotransferase activity in PC12 cells, Biochemical Pharmacology, 47(9): 1575-1580.
Nakamura et al., “Isolation and Expression Profiling of Genes Upregulated in Bone Marrow-Derived Mononuclear Cells of Rheumatoid Arthritis Patients,” DNA Research 13, pp. 169-183 (2006).

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