Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-01-11
2011-01-11
Desai, Anand U (Department: 1656)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S125000, C435S876000
Reexamination Certificate
active
07868138
ABSTRACT:
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4959312 (1990-09-01), Sirotkin
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4994368 (1991-02-01), Goodman et al.
patent: 4994379 (1991-02-01), Chang
patent: 5023171 (1991-06-01), Ho et al.
patent: 5043272 (1991-08-01), Hartley
patent: 5093257 (1992-03-01), Gray
patent: 5106727 (1992-04-01), Hartley et al.
patent: 5169764 (1992-12-01), Shooter et al.
patent: 5176995 (1993-01-01), Sninsky et al.
patent: 5187083 (1993-02-01), Mullis
patent: 5223408 (1993-06-01), Goeddel et al.
patent: 5234824 (1993-08-01), Mullis
patent: 5264563 (1993-11-01), Huse
patent: 5279952 (1994-01-01), Wu
patent: 5314809 (1994-05-01), Erlich et al.
patent: 5316935 (1994-05-01), Arnold et al.
patent: 5356801 (1994-10-01), Rambosek et al.
patent: 5360728 (1994-11-01), Prasher
patent: 5418149 (1995-05-01), Gelfand et al.
patent: 5422266 (1995-06-01), Cormier et al.
patent: 5470725 (1995-11-01), Borriss et al.
patent: 5489523 (1996-02-01), Mathur
patent: 5502167 (1996-03-01), Waldmann et al.
patent: 5512463 (1996-04-01), Stemmer
patent: 5514568 (1996-05-01), Stemmer
patent: 5521077 (1996-05-01), Khosla et al.
patent: 5523388 (1996-06-01), Huse
patent: 5541309 (1996-07-01), Prasher
patent: 5556750 (1996-09-01), Modrich
patent: 5556772 (1996-09-01), Sorge et al.
patent: 5571708 (1996-11-01), Yang et al.
patent: 5574205 (1996-11-01), Kucherlapati et al.
patent: 5605793 (1997-02-01), Stemmer
patent: 5625048 (1997-04-01), Tsien et al.
patent: 5629179 (1997-05-01), Mierendorf et al.
patent: 5652116 (1997-07-01), Grandi et al.
patent: 5679522 (1997-10-01), Modrich
patent: 5698426 (1997-12-01), Huse
patent: 5714316 (1998-02-01), Weiner et al.
patent: 5723323 (1998-03-01), Kauffman et al.
patent: 5741668 (1998-04-01), Ward et al.
patent: 5756316 (1998-05-01), Schellenberger
patent: 5763192 (1998-06-01), Kauffman et al.
patent: 5770434 (1998-06-01), Huse
patent: 5773267 (1998-06-01), Jacobs et al.
patent: 5783431 (1998-07-01), Peterson et al.
patent: 5795747 (1998-08-01), Henco et al.
patent: 5808022 (1998-09-01), Huse
patent: 5811238 (1998-09-01), Stemmer et al.
patent: 5814476 (1998-09-01), Kauffman et al.
patent: 5817483 (1998-10-01), Kauffman et al.
patent: 5824469 (1998-10-01), Horwitz et al.
patent: 5824485 (1998-10-01), Thompson et al.
patent: 5824514 (1998-10-01), Kauffman et al.
patent: 5830696 (1998-11-01), Short
patent: 5830721 (1998-11-01), Stemmer et al.
patent: 5834252 (1998-11-01), Stemmer et al.
patent: 5837458 (1998-11-01), Minshull et al.
patent: 5843643 (1998-12-01), Ratner
patent: 5851813 (1998-12-01), Desrosiers
patent: 5858725 (1999-01-01), Crowe et al.
patent: 5866363 (1999-02-01), Pieczenik
patent: 5871974 (1999-02-01), Huse
patent: 5877402 (1999-03-01), Maliga et al.
patent: 5925749 (1999-07-01), Mathur et al.
patent: 5928905 (1999-07-01), Stemmer et al.
patent: 5939250 (1999-08-01), Short
patent: 5955358 (1999-09-01), Huse
patent: 5958672 (1999-09-01), Short
patent: 5962258 (1999-10-01), Mathur et al.
patent: 5965408 (1999-10-01), Short
patent: 5965415 (1999-10-01), Radman
patent: 5976862 (1999-11-01), Kauffman et al.
patent: 6001574 (1999-12-01), Short et al.
patent: 6004788 (1999-12-01), Short
patent: 6030779 (2000-02-01), Short
patent: 6051409 (2000-04-01), Hansen et al.
patent: 6054267 (2000-04-01), Short
patent: 6057103 (2000-05-01), Short
patent: 6071889 (2000-06-01), Weiss et al.
patent: 6074853 (2000-06-01), Pati et al.
patent: 6087177 (2000-07-01), Wohlstadter
patent: 6087341 (2000-07-01), Khavari
patent: 6093873 (2000-07-01), Chambon et al.
patent: 6096548 (2000-08-01), Stemmer
patent: 6117679 (2000-09-01), Stemmer
patent: 6132970 (2000-10-01), Stemmer
patent: 6165793 (2000-12-01), Stemmer
patent: 6168919 (2001-01-01), Short
patent: 6171820 (2001-01-01), Short
patent: 6174673 (2001-01-01), Short
patent: 6180406 (2001-01-01), Stemmer
patent: 6277638 (2001-08-01), Stemmer
patent: 6287861 (2001-09-01), Stemmer et al.
patent: 6291242 (2001-09-01), Stemmer
patent: 6297053 (2001-10-01), Stemmer
patent: 6323030 (2001-11-01), Stemmer
patent: 6352842 (2002-03-01), Short et al.
patent: 6358709 (2002-03-01), Short et al.
patent: 6361974 (2002-03-01), Short et al.
patent: 6365408 (2002-04-01), Stemmer
patent: 2003/0013849 (2003-01-01), Ward et al.
patent: 2003/0219752 (2003-11-01), Short
patent: 252 666 (1998-12-01), None
patent: 544 809 (1998-12-01), None
patent: 563 296 (1999-03-01), None
patent: 552 266 (2000-01-01), None
patent: 876 509 (2001-09-01), None
patent: 911 396 (2001-09-01), None
patent: 1 138 763 (2001-10-01), None
patent: 934 999 (2002-01-01), None
patent: 752 008 (2002-04-01), None
patent: 2-303489 (1990-12-01), None
patent: WO 90/07576 (1990-07-01), None
patent: WO 90/14424 (1990-11-01), None
patent: WO 90/14430 (1990-11-01), None
patent: WO 91/01087 (1991-02-01), None
patent: WO 91/06570 (1991-05-01), None
patent: WO 91/06643 (1991-05-01), None
patent: WO 91/06645 (1991-05-01), None
patent: WO 91/07506 (1991-05-01), None
patent: WO 91/15581 (1991-10-01), None
patent: WO 91/16427 (1991-10-01), None
patent: WO 92/06176 (1992-04-01), None
patent: WO 92/07075 (1992-04-01), None
patent: WO 92/18645 (1992-10-01), None
patent: WO 93/01282 (1993-01-01), None
patent: WO 93/02191 (1993-02-01), None
patent: WO 93/06213 (1993-04-01), None
patent: WO 93/11237 (1993-06-01), None
patent: WO 93/12228 (1993-06-01), None
patent: WO 93/15208 (1993-08-01), None
patent: WO 93/16192 (1993-08-01), None
patent: WO 93/18141 (1993-09-01), None
patent: WO 93/19172 (1993-09-01), None
patent: WO 93/25237 (1993-12-01), None
patent: WO 94/03596 (1994-02-01), None
patent: WO 94/09817 (1994-05-01), None
patent: WO 94/11496 (1994-05-01), None
patent: WO 94/13804 (1994-06-01), None
patent: WO 95/17413 (1995-06-01), None
patent: WO 95/22625 (1995-08-01), None
patent: WO 96/17056 (1996-06-01), None
patent: WO 96/33207 (1996-10-01), None
patent: WO 97/07205 (1997-02-01), None
patent: WO 97/20078 (1997-06-01), None
patent: WO 97/25410 (1997-07-01), None
patent: WO 97/35957 (1997-10-01), None
patent: WO 97/35966 (1997-10-01), None
patent: WO 98/01581 (1998-01-01), None
patent: WO 98/27230 (1998-06-01), None
patent: WO 98/28416 (1998-07-01), None
patent: WO 98/41622 (1998-09-01), None
patent: WO 98/41623 (1998-09-01), None
patent: WO 98/41653 (1998-09-01), None
patent: WO 98/42832 (1998-10-01), None
patent: WO 99/29902 (1999-06-01), None
patent: WO 00/04190 (2000-01-01), None
patent: WO 00/06718 (2000-02-01), None
patent: WO 00/09727 (2000-02-01), None
patent: WO 00/18906 (2000-04-01), None
Adey et al., “Preparation of second-generation phage libraries,”Phage Disp. Pept. Proteins, eds. Kay et al., pp. 277-291 (1996).
Andersson et al., “Muller's ratchet decreases fitness of a DNA-based microbe”,PNAS, 93: 906-907 (Jan. 1996).
Arkin et al., “An Algorithm for Protein Engineering:. Simulations of Recursive Ensemble Mutagenesis”Proc. Natl. Acad. Sci. USA, 89(16):7811-7815 (1992).
Atreya et al., “Construction of in-frame chimeric plant genes by simplified PCR strategies,”Plant Mol. Biol., 19:517-522 (1992).
Balint et al., “Antibody Engineering By Parsimonious Mutagenesis”,Gene, 137(1):109-118 (1993).
Bailey, “Toward a Science of Metabolic Engineering”,Science, 252: 1668-1580 (1991).
Barrett et al., “Genotypic analysis of multiple loci in somatic cells by whole genome amplification”,Nuc. Acids Res., 23(17): 3488-3492 (1995).
Bartel et al., “Isolation of New Ribozymes From a Large Pool of Random Se
Crameri Andreas
Stemmer Willem P. C.
Codexis, Inc.
Desai Anand U
Hunter Tom
Liu Samuel
Weaver Austin Villeneuve & Sampson LLP
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