Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification
Reexamination Certificate
2006-02-07
2006-02-07
Whisenant, Ethan C. (Department: 1655)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
06995017
ABSTRACT:
A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
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Smi
Kruse Norman J.
Maxygen Inc.
Quine Jonathan Alan
The Law Offices of Jonathan Alan Quine
Whisenant Ethan C.
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